EGR1 Antikörper (AA 94-108)

Produktnummer ABIN129622

Produktdetails anti-EGR1 Antikörper

Target: EGR1 (Early Growth Response 1 (EGR1))

Bindungsspezifität: AA 94-108

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EGR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Schimpanse, Maus

Produktmerkmale: Concentration Definition: by UV absorbance at 280 nm

Immunogen: This affinity-purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 94-108 (eqpyehltaesfpdi) of Human EGR-1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: This affinity purified antibody has been tested for use in ELISA, immunohistochemistry and western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band at ~58 kDa in size corresponding to EGR-1 by western blotting in the appropriate cell lysate or extract.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.93 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Referenzen für anti-EGR1 Antikörper (ABIN129622)

Weaver, Hellstrom, Brown, Andrews, Dymov, Diorio, Zhang, Szyf, Meaney: "The methylated-DNA binding protein MBD2 enhances NGFI-A (egr-1)-mediated transcriptional activation of the glucocorticoid receptor." in: Philosophical transactions of the Royal Society of London. Series B, Biological sciences, Vol. 369, Issue 1652, (2015) (PubMed).

Hellstrom, Dhir, Diorio, Meaney: "Maternal licking regulates hippocampal glucocorticoid receptor transcription through a thyroid hormone-serotonin-NGFI-A signalling cascade." in: Philosophical transactions of the Royal Society of London. Series B, Biological sciences, Vol. 367, Issue 1601, pp. 2495-510, (2012) (PubMed).

Details zu EGR1

Target: EGR1 (Early Growth Response 1 (EGR1))

Andere Bezeichnung: EGR-1 (EGR1 Produkte)

Hintergrund: EGR-1 (also called Early Growth Response protein 1, Krox-24 protein, ZIF268, Nerve growth factor-induced protein A or NGFI-A, Transcription factor ETR103, and Zinc finger protein 225 or AT225) is a transcriptional regulator that recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3' (EGR-site).  EGR-1 activates the transcription of target genes whose products are required for mitogenesis and differentiation.   EGR-1 is a nuclear protein induced by growth factors. Expression has been identified in a variety of cancers.
Synonyms: AT225 antibody, Early growth response 1 antibody, G0S30 antibody, Krox 24 protein antibody, KROX24 antibody, Nerve growth factor-induced protein A antibody

Gen-ID: 1958

UniProt: P18146

Pathways: Regulation of Carbohydrate Metabolic Process, Regulation of long-term Neuronal Synaptic Plasticity