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DLL4 Antikörper (Internal Region)

Rockland 600-401-696 DLL4 Reaktivität: Human, Maus WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
Rockland
Produktnummer ABIN129625
Hersteller Produkt- Nr.: 600-401-696
  • Target Alle DLL4 Antikörper anzeigen
    DLL4 (delta-Like 4 (DLL4))
    Bindungsspezifität
    • 15
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 51
    • 38
    • 14
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Maus
    Wirt
    • 53
    • 17
    • 8
    • 5
    • 1
    Kaninchen
    Klonalität
    • 54
    • 29
    • 1
    Polyklonal
    Konjugat
    • 47
    • 8
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser DLL4 Antikörper ist unkonjugiert
    Applikation
    • 39
    • 28
    • 13
    • 13
    • 13
    • 13
    • 9
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Hersteller Produkt- Nr.
    600-401-696
    Hersteller
    Rockland
    Verwendungszweck
    DELTA-4 Antibody
    Kreuzreaktivität (Details)
    DELTA-4 affinity purified antibody is directed against human DELTA-4.
    Produktmerkmale
    Synonyms: rabbit anti-DELTA4 antibody, DELTA-4, delta 4 precursor, Delta-like protein 4, DLL4, Drosophila Delta homolog 4, notch ligand DLL4 precursor, DELTA 4
    Aufreinigung
    The product was affinity purified from monospecific antiserum by immunoaffinity chromatography.
    Sterilität
    Sterile filtered
    Immunogen

    Immunogen: Anti-DELTA-4 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region of Human DELTA-4.

    Immunogen Type: Conjugated Peptide

    Isotyp
    IgG
    Top Product
    Discover our top product DLL4 Primärantikörper
  • Applikationshinweise

    Immunohistochemistry Dilution: 10 μg/mL to 20 μg/mL

    Application Note: Anti-DELTA-4 has been tested for use in ELISA, immunohistochemistry and western blotting.  Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 74 kDa in size corresponding to DELTA-4 by western blotting in the appropriate cell lysate or extract. For best results use Goat Serum as blocking agent in western blotting.

    Western Blot Dilution: 1:500 - 1:2,500

    ELISA Dilution: 1:10,000 - 1:50,000

    Other: User Optimized

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.88 mg/mL
    Buffer

    Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

    Stabilizer: None

    Preservative: 0.01 % (w/v) Sodium Azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
    Haltbarkeit
    12 months
  • Wu, Esumi, Watanabe, Chen, Nakamura, Nakamura, Kometani, Minato, Yanagawa, Akashi, Sakimura, Kaneko, Tamamaki: "Tangential migration and proliferation of intermediate progenitors of GABAergic neurons in the mouse telencephalon." in: Development (Cambridge, England), Vol. 138, Issue 12, pp. 2499-509, (2011) (PubMed).

    Zhang, Zeng, Zhang, Jiao, Li, Jing, Ouyang, Yuan, Chai, Che, Zhang, Yang: "Suppressor of cytokine signaling 3 promotes bone marrow cells to differentiate into CD8+ T lymphocytes in lung tissue via up-regulating Notch1 expression." in: Cancer research, Vol. 69, Issue 4, pp. 1578-86, (2009) (PubMed).

    Indraccolo, Minuzzo, Masiero, Pusceddu, Persano, Moserle, Reboldi, Favaro, Mecarozzi, Di Mario, Screpanti, Ponzoni, Doglioni, Amadori: "Cross-talk between tumor and endothelial cells involving the Notch3-Dll4 interaction marks escape from tumor dormancy." in: Cancer research, Vol. 69, Issue 4, pp. 1314-23, (2009) (PubMed).

    Lauret, Catelain, Titeux, Poirault, Dando, Dorsch, Villeval, Groseil, Vainchenker, Sainteny, Bennaceur-Griscelli: "Membrane-bound delta-4 notch ligand reduces the proliferative activity of primitive human hematopoietic CD34+CD38low cells while maintaining their LTC-IC potential." in: Leukemia, Vol. 18, Issue 4, pp. 788-97, (2004) (PubMed).

    Tohda, Murata-Ohsawa, Sakano, Nara: "Notch ligands, Delta-1 and Delta-4 suppress the self-renewal capacity and long-term growth of two myeloblastic leukemia cell lines." in: International journal of oncology, Vol. 22, Issue 5, pp. 1073-9, (2003) (PubMed).

    Liu, Shirakawa, Li, Soma, Oka, Dotto, Fairman, Velazquez, Herlyn: "Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis." in: Molecular and cellular biology, Vol. 23, Issue 1, pp. 14-25, (2002) (PubMed).

  • Target
    DLL4 (delta-Like 4 (DLL4))
    Andere Bezeichnung
    DLL4 (DLL4 Produkte)
    Hintergrund
    Background: DELTA-4 (also called delta 4 precursor, delta ligand 4 precursor, Delta-like protein 4, DLL4, Drosophila Delta homolog 4 and notch ligand DLL4 precursor) is a homolog of the Drosophila delta protein. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.  DELTA-4  plays a role in the Notch signaling pathway and activates Notch-1 and Notch-4. DELTA-4 is a membrane protein that is expressed in the vascular endothelium.
    Gen-ID
    54567, 9506545
    UniProt
    Q9NR61
    Pathways
    Notch Signalweg
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