HDAC1 Antikörper (AA 466-482)

Produktnummer ABIN129652

Produktdetails anti-HDAC1 Antikörper

Target: HDAC1 (Histone Deacetylase 1 (HDAC1))

Bindungsspezifität: AA 466-482

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HDAC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktmerkmale: Concentration Definition: by UV absorbance at 280 nm

Immunogen: Anti-HDAC-1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 466-482 of Human HDAC-1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Anti-HDAC-1 Antibody has been tested for use in ELISA, immunohistochemistry and western blot.  Specific conditions for reactivity should be optimized by the end user.   Specific nuclear staining is observed by IHC.  Expect bands at 65 kDa in size corresponding to HDAC-1 by western blotting in the appropriate cell lysate or extract.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.33 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Referenzen für anti-HDAC1 Antikörper (ABIN129652)

Scharer, Barwick, Guo, Bally, Boss: "Plasma cell differentiation is controlled by multiple cell division-coupled epigenetic programs." in: Nature communications, Vol. 9, Issue 1, pp. 1698, (2018) (PubMed).

Nohata, Hanazawa, Kinoshita, Inamine, Kikkawa, Itesako, Yoshino, Enokida, Nakagawa, Okamoto, Seki: "Tumour-suppressive microRNA-874 contributes to cell proliferation through targeting of histone deacetylase 1 in head and neck squamous cell carcinoma." in: British journal of cancer, Vol. 108, Issue 8, pp. 1648-58, (2013) (PubMed).

Unoki, Nishidate, Nakamura: "ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain." in: Oncogene, Vol. 23, Issue 46, pp. 7601-10, (2004) (PubMed).

Details zu HDAC1

Target: HDAC1 (Histone Deacetylase 1 (HDAC1))

Andere Bezeichnung: HDAC-1 (HDAC1 Produkte)

Synonyme: GON-10 antikoerper, HD1 antikoerper, RPD3 antikoerper, RPD3L1 antikoerper, CG7471 antikoerper, DHDAC1 antikoerper, DRpd3 antikoerper, DmHDAC1 antikoerper, Dmel\\CG7471 antikoerper, E(var)3-64BC antikoerper, HDAC antikoerper, HDAC-1 antikoerper, HDAC1 antikoerper, Hdac1 antikoerper, Rpd3/HDAC antikoerper, Su(var)3-26 antikoerper, Su(var)326 antikoerper, Su(var)328 antikoerper, dHDAC-1 antikoerper, dHDAC1 antikoerper, dRPD3 antikoerper, dRpd3 antikoerper, dmHDA401 antikoerper, drpd3 antikoerper, hdac1 antikoerper, l(3)04556 antikoerper, l(3)64Cc antikoerper, rpd3 antikoerper, rpd[3] antikoerper, gon-10 antikoerper, hdac1b antikoerper, rpd3l1 antikoerper, Rpd3 antikoerper, GB14706 antikoerper, hdac1-b antikoerper, chunp6919 antikoerper, hdac-1 antikoerper, mp:zf637-2-001987 antikoerper, wu:fb19h11 antikoerper, wu:fi06f03 antikoerper, zgc:101582 antikoerper, zgc:65818 antikoerper, Hdac1-ps antikoerper, MommeD5 antikoerper, ARABIDOPSIS HISTONE DEACETYLASE 1 antikoerper, ARABIDOPSIS HISTONE DEACETYLASE 19 antikoerper, ATHD1 antikoerper, ATHDA19 antikoerper, ATRPD3A antikoerper, F20D10.250 antikoerper, F20D10_250 antikoerper, HDA1 antikoerper, HDA19 antikoerper, HISTONE DEACETYLASE antikoerper, HISTONE DEACETYLASE 19 antikoerper, HISTONE DEACETYLASE19 antikoerper, RPD3A antikoerper, histone deacetylase 1 antikoerper, HDM antikoerper, ab21 antikoerper, hdac1a antikoerper, histone deacetylase 1 antikoerper, Histone deacetylase 1 antikoerper, histone deacetylase antikoerper, histone deacetylase 1 S homeolog antikoerper, histone deacetylase Rpd3 antikoerper, histone deacetylase 1 L homeolog antikoerper, HDAC1 antikoerper, hdac1.S antikoerper, LOC411503 antikoerper, hdac1 antikoerper, Hdac1 antikoerper, HD1 antikoerper, hda-1 antikoerper, hdac1.L antikoerper, LOC748850 antikoerper

Hintergrund: HDAC-1 antibody recognizes HDAC1 (also known as HD1, histone deacetylase 1, RPD3, RPD3L1) which belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
Synonyms: GON 10 antibody, HD 1 antibody, hdac1: histone deacetylase 1 antibody, Histone deacetylase 1 (HD1) antibody, Histone deacetylase 1 antibody, RPD3 (reduced potassium dependency yeast homolog) like 1 antibody

Gen-ID: 3065, 13128860

UniProt: Q13547

Pathways: Neurotrophin Signalübertragung, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Mitotic G1-G1/S Phases, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Negative Regulation of intrinsic apoptotic Signaling, Embryonic Body Morphogenesis