Cyclin E2 Antikörper (C-Term)

Produktnummer ABIN129714

Produktdetails anti-Cyclin E2 Antikörper

Target: Cyclin E2 (CCNE2)

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cyclin E2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität: Human

Produktmerkmale: Concentration Definition: by UV absorbance at 280 nm

Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids at the of the Cyclin E2 protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: This affinity purified antibody has been tested for use in ELISA and western blotting.  Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 50 kDa in size corresponding to Cyclin E2 protein by western blotting in the appropriate cell lysate or extract.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.17 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu Cyclin E2

Target: Cyclin E2 (CCNE2)

Andere Bezeichnung: Cyclin E2 (CCNE2 Produkte)

Synonyme: ccne2 antikoerper, MGC53684 antikoerper, MGC132360 antikoerper, cb165 antikoerper, sb:cb165 antikoerper, zgc:86724 antikoerper, CCNE2 antikoerper, cyce2 antikoerper, CYCE2 antikoerper, cyclin E2 antikoerper, cyclin E2 L homeolog antikoerper, cyclin E1 L homeolog antikoerper, CCNE2 antikoerper, ccne2.L antikoerper, ccne2 antikoerper, ccne1.L antikoerper, Ccne2 antikoerper

Hintergrund: This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Cyclin E was first identified by its ability to rescue growth of yeast deficient in G1 Cyclins, indicating a role in G1 or G1/S transitions.  Over-expression of Cyclin E has been observed in a variety of human tumors. Multiple isoforms of Cyclin E are expressed in tumors but not in normal tissues, suggesting a post-transcriptional regulation of Cyclin E.  Cyclin E2 associates with Cdk2 in a functional kinase complex that is inhibited by both p27Kip1 and p21Cip1.  The catalytic activity associated with Cyclin E2 complexes is cell cycle regulated and peaks at the G1/S transition.  Unlike Cyclin E1, which is expressed in most proliferating normal and tumor cells, Cyclin E2 levels were low to undetectable in non-transformed cells and increased significantly in tumor-derived cells.
Synonyms: G1/S-specific cyclin-E2

Gen-ID: 12448, 3769612

UniProt: Q9Z238

Pathways: Zellzyklus, Mitotic G1-G1/S Phases