CCDC98 Antikörper (AA 1-313)
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- Target Alle CCDC98 (FAM175A) Antikörper anzeigen
- CCDC98 (FAM175A) (Family with Sequence Similarity 175, Member A (FAM175A))
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Bindungsspezifität
- AA 1-313
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser CCDC98 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunoprecipitation (IP), Flow Cytometry (FACS)
- Spezifität
- The mouse monoclonal antibody ABRA1-01 recognizes human ABRA1 (Abraxas, CCDC98), an adaptor protein involved in DNA repair, which migrates as a 45 kDa band on PAAGE under reducing conditions.
- Kreuzreaktivität (Details)
- Human, Other not tested
- Aufreinigung
- Purified by protein-A affinity chromatography.
- Reinheit
- > 95 % (by SDS-PAGE)
- Immunogen
- Recombinant protein corresponding to amino acids 1-313 of ABRA1 with N-terminal His6 tag
- Klon
- ABRA1-01
- Isotyp
- IgG
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anti-Family with Sequence Similarity 175, Member A (FAM175A) (AA 51-150) antibody
FAM175A Reaktivität: Maus WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Family with Sequence Similarity 175, Member A (FAM175A) (AA 1-313) antibodyFAM175A Reaktivität: Human WB, IP, IHC, IHC (p), FACS Wirt: Maus Monoclonal ABRA1-01 unconjugated
anti-Family with Sequence Similarity 175, Member A (FAM175A) (AA 350-400) antibodyFAM175A Reaktivität: Human WB, IP, IHC, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Family with Sequence Similarity 175, Member A (FAM175A) (N-Term) antibodyFAM175A Reaktivität: Human, Maus WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
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Flow cytometry: Recommended dilution: 1-2 μg/mL. Intracellular staining.
Western blotting: Reducing conditions. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Do not freeze.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Store at 2-8°C. Do not freeze.
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- Target
- CCDC98 (FAM175A) (Family with Sequence Similarity 175, Member A (FAM175A))
- Andere Bezeichnung
- ABRA1 (FAM175A Produkte)
- Hintergrund
- Abraxas 1, BRCA1 A complex subunit,ABRA1 (Abraxas), also known as CCDC98, is an adaptor protein that is essential for formation and function of BRCA1 A tumor suppressor complex. This complex plays critical roles in DNA repair, cell cycle checkpoint control, and maintenance of genomic stability. ABRA1 mediates interaction of ubiquitin-interacting motif-containing protein RAP80 and deubiquitination enzyme BRCC36 with BRCA1/BARD1. ABRA1 controls both DNA-damage-induced formation of BRCA1 foci and BRCA1-dependent G2/M checkpoint activation.,ABRA1, Abraxas 1, CCDC98, FAM175A
- Gen-ID
- 84142
- UniProt
- Q6UWZ7
- Pathways
- DNA Reparatur, Positive Regulation of Response to DNA Damage Stimulus
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