CCDC98 Antikörper (AA 1-313)

Produktnummer ABIN1302443

Der Maus Monoklonal Anti-CCDC98-Antikörper wurde für WB, IP und ICFC validiert. Er ist geeignet, CCDC98 in Proben von Human zu detektieren.

Kurzübersicht für CCDC98 Antikörper (AA 1-313) (ABIN1302443)

Target: CCDC98 (FAM175A) (Family with Sequence Similarity 175, Member A (FAM175A))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CCDC98 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Intracellular Flow Cytometry (ICFC)

Klon: ABRA1-01

Produktdetails anti-CCDC98 Antikörper

Bindungsspezifität: AA 1-313

Verwendungszweck: Anti-ABRA1 Purified

Spezifität: The mouse monoclonal antibody ABRA1-01 recognizes human ABRA1 (Abraxas, CCDC98), an adaptor protein involved in DNA repair, which migrates as a 45 kDa band on PAAGE under reducing conditions.

Kreuzreaktivität (Details): Human, Other not tested

Aufreinigung: Purified by protein-A affinity chromatography.

Reinheit: > 95 % (by SDS-PAGE)

Immunogen: Recombinant protein corresponding to amino acids 1-313 of ABRA1 with N-terminal His6 tag

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Flow cytometry: Recommended dilution: 1-2 μg/mL. Intracellular staining.
Western blotting: Reducing conditions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze.

Details zu CCDC98

Target: CCDC98 (FAM175A) (Family with Sequence Similarity 175, Member A (FAM175A))

Andere Bezeichnung: ABRA1

Hintergrund: Abraxas 1, BRCA1 A complex subunit,ABRA1 (Abraxas), also known as CCDC98, is an adaptor protein that is essential for formation and function of BRCA1 A tumor suppressor complex. This complex plays critical roles in DNA repair, cell cycle checkpoint control, and maintenance of genomic stability. ABRA1 mediates interaction of ubiquitin-interacting motif-containing protein RAP80 and deubiquitination enzyme BRCC36 with BRCA1/BARD1. ABRA1 controls both DNA-damage-induced formation of BRCA1 foci and BRCA1-dependent G2/M checkpoint activation.,ABRA1, Abraxas 1, CCDC98, FAM175A

Gen-ID: 84142

UniProt: Q6UWZ7

Pathways: DNA Reparatur, Positive Regulation of Response to DNA Damage Stimulus