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SCIMP Antikörper

SCIMP Reaktivität: Human FACS, IP, WB, ICC Wirt: Maus Monoclonal NVL-07 unconjugated
Produktnummer ABIN1302508
  • Target Alle SCIMP Antikörper anzeigen
    SCIMP (SLP Adaptor and CSK Interacting Membrane Protein (SCIMP))
    Reaktivität
    Human
    Wirt
    • 19
    • 3
    Maus
    Klonalität
    • 19
    • 3
    Monoklonal
    Konjugat
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SCIMP Antikörper ist unkonjugiert
    Applikation
    • 13
    • 13
    • 6
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB), Immunocytochemistry (ICC)
    Spezifität
    The mouse monoclonal antibody NVL-07 recognizes intracellular part of human transmembrane adaptor SCIMP. This protein of 17 kDa predicted Mw migrates as a 22 kDa band on SDS PAGE.
    Kreuzreaktivität (Details)
    Human
    Aufreinigung
    Purified by protein-A affinity chromatography.
    Reinheit
    > 95 % (by SDS-PAGE)
    Immunogen
    Recombinant intracellular part of human SCIMP
    Klon
    NVL-07
    Isotyp
    IgG2a
  • Applikationshinweise
    Flow cytometry: Intracellular staining.
    Western blotting: Recommended dilution: 1-2 μg/mL.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Do not freeze.
  • Draber, Vonkova, Stepanek, Hrdinka, Kucova, Skopcova, Otahal, Angelisova, Horejsi, Yeung, Weiss, Brdicka: "SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling." in: Molecular and cellular biology, Vol. 31, Issue 22, pp. 4550-62, (2011) (PubMed).

  • Target
    SCIMP (SLP Adaptor and CSK Interacting Membrane Protein (SCIMP))
    Andere Bezeichnung
    SCIMP (SCIMP Produkte)
    Synonyme
    C17orf87 antikoerper, UNQ5783 antikoerper, A430084P05Rik antikoerper, SLP adaptor and CSK interacting membrane protein antikoerper, SCIMP antikoerper, Scimp antikoerper
    Hintergrund
    SLP adaptor and CSK interacting membrane protein,SCIMP (SLP adaptor and Csk interacting membrane protein), also known as Nvl, is a palmitoylated transmembrane adaptor protein expressed in professional antigen presenting cells, most prominently in the lymph nodes and spleen. It is associated with tetraspanin-enriched microdomains (together with MHC II). There is a close relationship between SCIMP and tyrosinkinase Lyn, which is constitutively bound to it by its SH3 domain. After MHC II-mediated stimulation in the immunological synapse SCIMP becomes phosphorylated at several tyrosine residues and provides docking sites for Grb2 and SLP65 or SLP76 adaptors transducing the signal downstream, as well as for the kinase Csk with modulatory roles.,NVL
    Gen-ID
    388325
    UniProt
    Q6UWF3
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