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FLT3 Antikörper (APC)

FLT3 Reaktivität: Human FACS Wirt: Maus Monoclonal BV10A4 APC
Produktnummer ABIN1302621
  • Target Alle FLT3 Antikörper anzeigen
    FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))
    Reaktivität
    • 144
    • 58
    • 7
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 144
    • 16
    • 6
    • 1
    Maus
    Klonalität
    • 145
    • 22
    Monoklonal
    Konjugat
    • 68
    • 14
    • 10
    • 8
    • 8
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    Dieser FLT3 Antikörper ist konjugiert mit APC
    Applikation
    • 114
    • 69
    • 42
    • 42
    • 36
    • 21
    • 20
    • 12
    • 9
    • 8
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Spezifität
    The mouse monoclonal antibody BV10A4 (BV10) reacts with an extracellular epitope of CD135 (FLT3, FLK2, STK-1), a 130-160 kDa type I transmembrane receptor tyrosine kinase that is involved in early steps of hematopoiesis.
    Keine Kreuzreaktivität
    Maus
    Kreuzreaktivität (Details)
    Human
    Aufreinigung
    Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogen
    BV-173 leukemic cell line
    Klon
    BV10A4
    Isotyp
    IgG1
    Top Product
    Discover our top product FLT3 Primärantikörper
  • Applikationshinweise
    Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
    Kommentare

    The purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Target
    FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))
    Andere Bezeichnung
    CD135 (FLT3 Produkte)
    Synonyme
    FLT3 antikoerper, B230315G04 antikoerper, CD135 antikoerper, Flk-2 antikoerper, Flk2 antikoerper, Flt-3 antikoerper, Ly72 antikoerper, wmfl antikoerper, FLK-2 antikoerper, FLK2 antikoerper, STK1 antikoerper, fms related tyrosine kinase 3 antikoerper, FMS-like tyrosine kinase 3 antikoerper, fms-related tyrosine kinase 3 antikoerper, FLT3 antikoerper, Flt3 antikoerper
    Hintergrund
    Fms related tyrosine kinase 3,CD135 / FLT3, also known as FLK2 or STK-1 is a receptor tyrosine kinase that plays important roles in hematopoiesis. After binding of Flt3 ligand (FL), CD135 homodimerizes and stimulates proliferation, differentiation and protects the cell from apoptosis. The loss of CD90 and gain of CD135 expression marks the loss of self-renewal in hematopoietic stem cell population. Detectable CD135 expression appears first at low levels on the surface of primitive multilineage progenitor cells and disappears during defined stages of B-cell development, but is upregulated and maintained during maturation of monocytes. CD135 is also expressed on thymocytes, dendritic cell progenitors and on mature dendritic cells, as well as on various malignant hematopoietic cells.,FLT3, FLK2, STK1
    Gen-ID
    2322
    UniProt
    P36888
    Pathways
    RTK Signalweg
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