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CD84 Antikörper (FITC)

CD84 Reaktivität: Human FACS Wirt: Maus Monoclonal CD84-1-21 FITC
Produktnummer ABIN1302945
  • Target Alle CD84 Antikörper anzeigen
    CD84
    Reaktivität
    • 64
    • 25
    • 16
    • 1
    Human
    Wirt
    • 51
    • 29
    • 3
    Maus
    Klonalität
    • 51
    • 31
    • 1
    Monoklonal
    Konjugat
    • 33
    • 7
    • 7
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CD84 Antikörper ist konjugiert mit FITC
    Applikation
    • 46
    • 43
    • 25
    • 10
    • 9
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    Flow Cytometry (FACS)
    Spezifität
    The mouse monoclonal antibody CD84.1.21 recognizes an extracellular epitope of CD84, a single chain cell surface glycoprotein of 64-82 kDa, predominantly expressed B cells, monocytes, platelets and some T cells.
    Kreuzreaktivität (Details)
    Human
    Aufreinigung
    Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogen
    CD84-transfected 300.19 cell line
    Klon
    CD84-1-21
    Isotyp
    IgG2a kappa
    Top Product
    Discover our top product CD84 Primärantikörper
  • Applikationshinweise
    Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.
    Kommentare

    The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Rekonstitution
    No reconstitution is necessary.
    Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze.
    Avoid prolonged exposure to light.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Romero, Zapater, Calvo, Kalko, de la Fuente, Tovar, Ockeloen, Pizcueta, Engel: "CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 11, pp. 7033-42, (2005) (PubMed).

    Morra, Lu, Poy, Martin, Sayos, Calpe, Gullo, Howie, Rietdijk, Thompson, Coyle, Denny, Yaffe, Engel, Eck, Terhorst: "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells." in: The EMBO journal, Vol. 20, Issue 21, pp. 5840-52, (2001) (PubMed).

    Martin, Romero, de la Fuente, Tovar, Zapater, Esplugues, Pizcueta, Bosch, Engel: "CD84 functions as a homophilic adhesion molecule and enhances IFN-gamma secretion: adhesion is mediated by Ig-like domain 1." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 7, pp. 3668-76, (2001) (PubMed).

    Sayós, Martín, Chen, Simarro, Howie, Morra, Engel, Terhorst: "Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP." in: Blood, Vol. 97, Issue 12, pp. 3867-74, (2001) (PubMed).

  • Target
    CD84
    Andere Bezeichnung
    CD84 (CD84 Produkte)
    Synonyme
    RGD1564553 antikoerper, A130013D22Rik antikoerper, CDw84 antikoerper, SLAMF5 antikoerper, LY9B antikoerper, hCD84 antikoerper, mCD84 antikoerper, CD84 molecule antikoerper, CD84 antigen antikoerper, Cd84 antikoerper, CD84 antikoerper
    Hintergrund
    CD84 Molecule,CD84 is a highly glycosylated homophilic receptor of SLAM family. It is expressed on platelets and various types of leukocytes, especially following their activation. Ligation of CD84 leads to its phosphorylation on tyrosine residues within the cytoplasmic tail. These docking sites are recognized by downstream signaling molecules, such as phosphatase SHP-2 and adaptor protein SAP/SH2D1A. The function of CD84 has not been fully elucidated yet. Although predominantly activating receptor, its modulating activity was also demonstrated.,LY9B, SLAMF5
    Gen-ID
    8832
    UniProt
    Q9UIB8
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