CD8 Antikörper (PE,Cy5)

Produktnummer ABIN133193

Produktdetails anti-CD8 Antikörper (PE,Cy5)

Target: CD8

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD8 Antikörper ist konjugiert mit PE,Cy5

Applikation: Flow Cytometry (FACS)

Spezifität: Rat CD8a

Aufreinigung: Ion exchange

Klon: OX-8

Isotyp: IgG1

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.2 mg/ml

Lagerung: 4 °C

Details zu CD8

Target: CD8

Andere Bezeichnung: CD8 (CD8 Produkte)

Synonyme: CD8 antikoerper, Leu2 antikoerper, MAL antikoerper, p32 antikoerper, CD8a molecule antikoerper, CD8A antikoerper

Hintergrund: Anti-rat CD8a monoclonal antibody recognizes a determinant on the majority of thymocytes (90-95%), a subset of peripheral T cells, the majority of NK cells, and the granular intraepithelial leukocytes in the small intestine. (1,2,3,4.) The antigen recognized is a complex of surface glycoproteins of Mr 34,000, 39,000 and 76,000 Da and is the rat homologue of the human CD8 and the mouse Ly-2,3 antigen. (5,8) ABIN133193labels all peripheral T cells that are unlabelled by the ABIN000000 (W3/25) monoclonal antibody. It labels a T-cell subset which mediates the suppression of antibody formation (1) and the cytotoxic cell precursor. (2) ABIN133193and ABIN000000 can be used together to fractionate T cells by sorting in FACS or by rosette depletion (1,2) or can be used together to study subsets of T cells in the rat which mediate lethal graft vs. host disease. (7) This antibody is one of the 3 monoclonal antibodies which labels T lymphocyte populations in the rat, these being ABIN000000 (W3/13) which labels all T cells, as well as ABIN000000 (W3/25) and CL004TC(MRC 0X-8) which label non-overlapping T cell populations. These monoclonal antibodies used in concert are being employed extensively to investigate cellular aspects of the immune response in rats and prove to be useful as markers for functionally distinct subpopulations of lymphocytes.