H2-D1 Antikörper

Produktnummer ABIN135412

Produktdetails anti-H2-D1 Antikörper

Target: H2-D1 (Histocompatibility 2, D Region Locus 1 (H2-D1))

Reaktivität: Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser H2-D1 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Spezifität: Mouse H-2Db

Produktmerkmale: Mouse Anti-Mouse H-2Db-UNLB

Aufreinigung: Purified

Immunogen: C3H.SW mouse splenocytes

Klon: 28-14-8

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise:

• Applications: FC - Quality tested , IHC-FS - Reported in literature , IP - Reported in literature , Block - Reported in literature , CMCD - Reported in literature
• Working Dilutions: Flow Cytometry Purified (UNLB) antibody 1 g/106 cells FITC, BIOT, and AF488 conjugates 1 g/106 cells PE conjugate 0.5 g/106 cells APC conjugate 0.1 g/106 cells For flow cytometry, the suggested use of these reagents is in a final volume of 100 L

Kommentare:

Complement-mediated cytotoxicity

Probenmenge: 1 mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: 0.5 mg of purified immunoglobulin in 1.0 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added

Konservierungsmittel: Without preservative

Handhabung: Each reagent is stable for the period shown on the bottle label if stored as directed.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C

Details zu H2-D1

Target: H2-D1 (Histocompatibility 2, D Region Locus 1 (H2-D1))

Andere Bezeichnung: H-2Db (H2-D1 Produkte)

Synonyme: H-2D antikoerper, H2-D antikoerper, histocompatibility 2, D region locus 1 antikoerper, H2-D1 antikoerper

Hintergrund: The classical MHC Class I molecules are histocompatibility antigens encoded by the H-2 gene complex and consist of heterodimers of highly polymorphic chains noncovalently associated with the invariant 2-microglobulin. These antigens are expressed on most nucleated cells but expression varies on different cell types. MHC Class I molecules present endogenously synthesized peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells.5 MHC Class I antigens expressed on thymic epithelial cells regulate the positive and negative selection of CD8+ T cells during T cell ontogeny.

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process