CD130/gp130 Antikörper

Produktnummer ABIN1383682

Dieses Maus Monoklonal-Antikörper erkennt spezifisch CD130/gp130 in IHC, ELISA, FACS, IP und Func. Er zeigt eine Reaktivität gegenüber Human und wurde in 15+ Publikationen erwähnt.

Kurzübersicht für CD130/gp130 Antikörper (ABIN1383682)

Target: CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD130/gp130 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP), Functional Studies (Func)

Klon: B-P8

Produktdetails anti-CD130/gp130 Antikörper

Spezifität: Recognises the Gp130, common subunit for IL-6, IL-11, OSM, LIF, CNTF, CT-1 receptors, a 130-140 kDa protein

Aufreinigung: Ion exchange chromatography

Sterilität: 0.22 μm filtered

Immunogen: Natural soluble gp130,Myeloma X63/AG.8653 x Balb/c spleen cells

Isotyp: IgG1 kappa

Biological Activity Comment: Inhibits CNTF activity and binding to gp130. Induces gp130 activation, Jak 1, Jak 2, Stat 1 and Stat 3 phosphorylation

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Phosphate-buffered saline. Sterile-filtered through 0.22 μm. Carrier and preservative free

Konservierungsmittel: Without preservative

Lagerung: 4 °C

Informationen zur Lagerung: Stable at +2-8°C for 12 months. For longer storage freeze aliquots.

Referenzen für anti-CD130/gp130 Antikörper (ABIN1383682)

Giese, Roderburg, Sommerauer, Wortmann, Metz, Heinrich, Müller-Newen: "Dimerization of the cytokine receptors gp130 and LIFR analysed in single cells." in: Journal of cell science, Vol. 118, Issue Pt 21, pp. 5129-40, (2005) (PubMed).

Giese, Au-Yeung, Herrmann, Diefenbach, Haan, Küster, Wortmann, Roderburg, Heinrich, Behrmann, Müller-Newen: "Long term association of the cytokine receptor gp130 and the Janus kinase Jak1 revealed by FRAP analysis." in: The Journal of biological chemistry, Vol. 278, Issue 40, pp. 39205-13, (2003) (PubMed).

Timmermann, Küster, Kurth, Heinrich, Müller-Newen: "A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor." in: European journal of biochemistry / FEBS, Vol. 269, Issue 11, pp. 2716-26, (2002) (PubMed).

Aoki, Narazaki, Kishimoto, Tosato: "Receptor engagement by viral interleukin-6 encoded by Kaposi sarcoma-associated herpesvirus." in: Blood, Vol. 98, Issue 10, pp. 3042-9, (2001) (PubMed).

Kurth, Horsten, Pflanz, Timmermann, Küster, Dahmen, Tacken, Heinrich, Müller-Newen: "Importance of the membrane-proximal extracellular domains for activation of the signal transducer glycoprotein 130." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 1, pp. 273-82, (2000) (PubMed).

Olivier, Auguste, Chabbert, Lelièvre, Chevalier, Gascan: "Identification of a gp130 cytokine receptor critical site involved in oncostatin M response." in: The Journal of biological chemistry, Vol. 275, Issue 8, pp. 5648-56, (2000) (PubMed).

Gu, De Vos, Rebouissou, Jourdan, Zhang, Rossi, Wijdenes, Klein: "Agonist anti-gp130 transducer monoclonal antibodies are human myeloma cell survival and growth factors." in: Leukemia, Vol. 14, Issue 1, pp. 188-97, (2000) (PubMed).

Müller-Newen, Küster, Wijdenes, Schaper, Heinrich: "Studies on the interleukin-6-type cytokine signal transducer gp130 reveal a novel mechanism of receptor activation by monoclonal antibodies." in: The Journal of biological chemistry, Vol. 275, Issue 7, pp. 4579-86, (2000) (PubMed).

Rebouissou, Wijdenes, Autissier, Tarte, Costes, Liautard, Rossi, Brochier, Klein: "A gp130 interleukin-6 transducer-dependent SCID model of human multiple myeloma." in: Blood, Vol. 91, Issue 12, pp. 4727-37, (1998) (PubMed).

Simpson, Hammacher, Smith, Matthews, Ward: "Interleukin-6: structure-function relationships." in: Protein science : a publication of the Protein Society, Vol. 6, Issue 5, pp. 929-55, (1997) (PubMed).

Lebeau, Montero Julian, Wijdenes, Müller-Newen, Dahmen, Chérel, Heinrich, Brailly, Hallet, Godard, Minvielle, Jacques: "Reconstitution of two isoforms of the human interleukin-11 receptor and comparison of their functional properties." in: FEBS letters, Vol. 407, Issue 2, pp. 141-7, (1997) (PubMed).

Horsten, Müller-Newen, Gerhartz, Wollmer, Wijdenes, Heinrich, Grötzinger: "Molecular modeling-guided mutagenesis of the extracellular part of gp130 leads to the identification of contact sites in the interleukin-6 (IL-6).IL-6 receptor.gp130 complex." in: The Journal of biological chemistry, Vol. 272, Issue 38, pp. 23748-57, (1997) (PubMed).

Wijdenes, Heinrich, Müller-Newen, Roche, Gu, Clément, Klein: "Interleukin-6 signal transducer gp130 has specific binding sites for different cytokines as determined by antagonistic and agonistic anti-gp130 monoclonal antibodies." in: European journal of immunology, Vol. 25, Issue 12, pp. 3474-81, (1996) (PubMed).

Gu, Wijdenes, Zhang, Hallet, Clement, Klein: "Anti-gp130 transducer monoclonal antibodies specifically inhibiting ciliary neurotrophic factor, interleukin-6, interleukin-11, leukemia inhibitory factor or oncostatin M." in: Journal of immunological methods, Vol. 190, Issue 1, pp. 21-7, (1996) (PubMed).

Chevalier, Fourcin, Robledo, Wijdenes, Pouplard-Barthelaix, Gascan: "Interleukin-6 family of cytokines induced activation of different functional sites expressed by gp130 transducing protein." in: The Journal of biological chemistry, Vol. 271, Issue 25, pp. 14764-72, (1996) (PubMed).

Details zu CD130/gp130

Target: CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))

Andere Bezeichnung: CD130

Hintergrund: Gp130

Molekulargewicht: 130-140 kDa

Pathways: JAK-STAT Signalweg, Cellular Glucan Metabolic Process, Autophagie, Smooth Muscle Cell Migration, Cancer Immune Checkpoints