Complement C3b Antikörper (AA 581-667)

Produktnummer ABIN1385282

Produktdetails anti-Complement C3b Antikörper

Target: Complement C3b (C3b) (Complement C3 beta Chain (C3b))

Bindungsspezifität: AA 581-667

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Complement C3b Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), ELISA

Spezifität: This antibody could recognize C3-beta-c

Kreuzreaktivität: Human, Maus

Homologie: Rat,Dog,Cow,Pig,Horse,Guinea Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Complement C3 beta chain

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-Complement C3b Antikörper (ABIN1385282)

Magliarelli, Matondo, Mészáros, Goginashvili, Erbs, Zhang, Mihlan, Wolfrum, Aebersold, Sumara, Ricci: "Liver ubiquitome uncovers nutrient-stress-mediated trafficking and secretion of complement C3." in: Cell death & disease, Vol. 7, Issue 10, pp. e2411, (2016) (PubMed).

Details zu Complement C3b

Target: Complement C3b (C3b) (Complement C3 beta Chain (C3b))

Andere Bezeichnung: Complement C3 beta chain (C3b Produkte)

Synonyme: AHUS5 antikoerper, ARMD9 antikoerper, ASP antikoerper, C3a antikoerper, C3b antikoerper, CPAMD1 antikoerper, AI255234 antikoerper, HSE-MSF antikoerper, Plp antikoerper, complement C3 antikoerper, complement component 3 antikoerper, C3 antikoerper

Hintergrund:

Synonyms: ASP, C3a, C3b, AHUS5, ARMD9, CPAMD1, HEL-S-62p, Complement C3, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, C3, CO3_HUMAN

Background: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils (By similarity). It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C3-beta-c: Acts as a chemoattractant for neutrophils in chronic inflammation. Acylation stimulating protein: adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2 (PubMed:8376604, PubMed:2909530, PubMed:9059512, PubMed:10432298, PubMed:15833747, PubMed:16333141, PubMed:19615750).

Gen-ID: 718

UniProt: P01024

Pathways: Komplementsystem, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Regulation of G-Protein Coupled Receptor Protein Signaling