CLNS1A Antikörper

Produktnummer ABIN1385503

Produktdetails anti-CLNS1A Antikörper

Target: CLNS1A (Chloride Channel, Nucleotide-Sensitive, 1A (CLNS1A))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CLNS1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CLNS1A/pICln

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu CLNS1A

Target: CLNS1A (Chloride Channel, Nucleotide-Sensitive, 1A (CLNS1A))

Andere Bezeichnung: CLNS1A (CLNS1A Produkte)

Synonyme: CLCI antikoerper, CLNS1B antikoerper, ICln antikoerper, 2610036D06Rik antikoerper, 2610100O04Rik antikoerper, Clci antikoerper, Clcni antikoerper, ICLN antikoerper, Icln antikoerper, pICln antikoerper, clci antikoerper, clns1b antikoerper, icln antikoerper, pIcIn antikoerper, chloride nucleotide-sensitive channel 1A antikoerper, chloride channel, nucleotide-sensitive, 1A antikoerper, chloride channel, nucleotide-sensitive, 1A L homeolog antikoerper, CLNS1A antikoerper, Clns1a antikoerper, clns1a.L antikoerper, clns1a antikoerper

Hintergrund:

Synonyms: nucleotide sensitive 1A, Chloride channel, Chloride channel nucleotide sensitive 1A, Chloride channel regulatory protein, Chloride conductance regulatory protein ICln, Chloride ion current inducer protein, ClCI, CLNS 1A, Clns1a, CLNS1B, ICln, ICln, ICLN_HUMAN, Methylosome subunit pICln, Reticulocyte pICln

Background: The formation of the spliceosome includes the assembly of Sm proteins in an ordered manner onto snRNAs. This process is mediated by the survival of motor neuron (SMN) protein, and is enhanced by modification of specific arginine residues in the Sm proteins to symmetrical dimethylarginines (sDMAs). sDMA modification of Sm proteins is catalyzed by the methylosome, a complex comprised of the type II methyltransferase PRMT5 (also designated Jak-binding protein 1, JBP1), pICln, and two novel factors. PRMT5 binds the Sm proteins via their arginine- and glycine-rich (RG) domains, while pICln binds the Sm domains. pICln also acts as an inhibitor of SnRNP assembly by preventing specific interactions between Sm proteins required for the formation of the Sm core. pICln is a highly conserved, ubiquitously expressed protein that localizes primarily to the cytoplasm, and may play a role as a swelling-activated anion channel or a channel regulator in addition to its function in the methylosome. The gene encoding human pICln maps to chromosome 11q14.1.

Gen-ID: 1207

Pathways: Ribonucleoprotein Complex Subunit Organization