UBE2G1 Antikörper (AA 101-170)

Produktnummer ABIN1385714

Produktdetails anti-UBE2G1 Antikörper

Target: UBE2G1 (Ube2g1) (Ubiquitin-Conjugating Enzyme E2G 1 (Ube2g1))

Bindungsspezifität: AA 101-170

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UBE2G1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Ratte

Homologie: Mouse,Dog,Sheep,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Ube2G1/UBC7

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu UBE2G1

Target: UBE2G1 (Ube2g1) (Ubiquitin-Conjugating Enzyme E2G 1 (Ube2g1))

Andere Bezeichnung: Ube2G1 (Ube2g1 Produkte)

Synonyme: E217K antikoerper, UBC7 antikoerper, UBE2G antikoerper, 2700059C12Rik antikoerper, AI256795 antikoerper, AU014992 antikoerper, AW552068 antikoerper, D130023C12Rik antikoerper, Ubc7 antikoerper, e217k antikoerper, ubc7 antikoerper, ube2g antikoerper, UB2G1 antikoerper, ube2g1 antikoerper, ubiquitin conjugating enzyme E2 G1 antikoerper, ubiquitin-conjugating enzyme E2G 1 antikoerper, ubiquitin-conjugating enzyme E2 G1 antikoerper, ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) antikoerper, ubiquitin conjugating enzyme E2 G1 S homeolog antikoerper, UBE2G1 antikoerper, Ube2g1 antikoerper, EDI_082630 antikoerper, Bm1_26310 antikoerper, ube2g1 antikoerper, ube2g1.S antikoerper

Hintergrund:

Synonyms: E217K, UB2G1_HUMAN, UBC 7, UBC7, UBC7 homolog yeast, UBE 2G, UBE2G, Ube2g1, Ubiquitin carrier protein G1, Ubiquitin conjugating enzyme E2 G1, Ubiquitin conjugating enzyme E2G 1 homologous to C. elegans UBC7, Ubiquitin conjugating enzyme E2G 1 UBC7 homolog C. elegans, Ubiquitin conjugating enzyme E2G 1 UBC7 homolog yeast, Ubiquitin conjugating enzyme E2G 1, Ubiquitin protein ligase G1, Ubiquitin-conjugating enzyme E2 G1, Ubiquitin-protein ligase G1.

Background: Ubiquitin is an abundant, highly conserved protein found in all eukaryotic cells either free or covalently attached to cellular proteins. The primary function of ubiquitin in mammalian systems is to clear abnormal, foreign, and improperly folded proteins by targeting them for proteosome degradation. In Saccharomyces cerevisiae, ubiquitin-like proteins include Rub1, Ula1, Uba3, Smt3, Ubc2, Ubc12 and Ubc9. Rub1 shares 53 % homology with ubiquitin and requires activation via the E2 proteins, including Ula1, Uba3 and Ubc12 in order to conjugate to substrates directed to different proteolytic systems. Ubc4 catalyzes ubiquitination of IkBa in a phosphorylation and SCFB-TRCP dependent manner. In this particular reaction, E1 first transfers ubiquitin to the E2 component Ubc4, and Ubc4 then associates with E3 ligase, which conjugates the poly-ubiquitin chain on a target protein. In this fashion, the chain tags the IkBa for degradation by a proteasome thus lifting the inhibitory effect of IkBa on NFkB and allowing NFkB to enter the nucleus.

Gen-ID: 7326