EBF2 Antikörper (AA 331-400)

Produktnummer ABIN1385751

Produktdetails anti-EBF2 Antikörper

Target: EBF2 (Early B-Cell Factor 2 (EBF2))

Bindungsspezifität: AA 331-400

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EBF2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human EBF2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-EBF2 Antikörper (ABIN1385751)

Bradshaw, Trossbach, Köber, Walter, Prikulis, Weggen, Korth: "Disrupted in Schizophrenia 1 regulates the processing of reelin in the perinatal cortex." in: Schizophrenia research, Vol. 215, pp. 506-513, (2021) (PubMed).

Details zu EBF2

Target: EBF2 (Early B-Cell Factor 2 (EBF2))

Andere Bezeichnung: EBF2 (EBF2 Produkte)

Synonyme: EBF2 antikoerper, Zcoe2 antikoerper, D14Ggc1e antikoerper, EBF-2 antikoerper, Mmot1 antikoerper, O/E-3 antikoerper, OE-3 antikoerper, EBF-2-A antikoerper, Xcoe-2 antikoerper, Xcoe2 antikoerper, Xebf-2 antikoerper, Xebf-2-A antikoerper, Xebf2 antikoerper, coe2 antikoerper, coe2-a antikoerper, ebf2 antikoerper, oe3 antikoerper, COE2 antikoerper, early B-cell factor 2 antikoerper, early B cell factor 2 antikoerper, early B-cell factor 2 S homeolog antikoerper, EBF2 antikoerper, ebf2 antikoerper, Ebf2 antikoerper, ebf2.S antikoerper

Hintergrund:

Synonyms: COE 2, COE2, Collier Olf and EBF 2, Early B cell factor 2, EBF 2, FLJ11500, Metencephalon mesencephalnon olfactory transcription factor 1, O/E 3, O/E3, OE 3, OE3, OLF 1/EBF like 3, Transcription factor COE2, COE2_HUMAN.

Background: Early B-cell factor 2 is a 575 amino acid protein belonging to the COE family of proteins, whose members are all helix-loop-helix transcription factors. EBF2 is a transcription factor which, in synergy with the Wnt-responsive LEF1/CTNNB1 pathway, activates the decoy receptor for RANKL, OPG, in osteoblasts. OPG, in turn, regulates osteoclast differentiation. Lack of EBF2 has been found to cause a small defect in the terminal differentiation of osteoblasts, along with reduced bone mass and an increase in osteoclasts. Localized to the nucleus, EBF2 forms a homodimer or a heterodimer with a related family member.

Gen-ID: 64641

UniProt: Q9HAK2