MKRN2 Antikörper

Produktnummer ABIN1385984

Produktdetails anti-MKRN2 Antikörper

Target: MKRN2 (Makorin Ring Finger Protein 2 (MKRN2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MKRN2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MKRN2/RNF62

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu MKRN2

Target: MKRN2 (Makorin Ring Finger Protein 2 (MKRN2))

Andere Bezeichnung: RNF62 (MKRN2 Produkte)

Synonyme: MKRN2 antikoerper, RNF62 antikoerper, MGC131105 antikoerper, mkrn2 antikoerper, Makorin-2 antikoerper, hspc070 antikoerper, wu:fb99a04 antikoerper, 2610002L04Rik antikoerper, C81377 antikoerper, makorin ring finger protein 2 antikoerper, makorin ring finger protein 2 pseudogene antikoerper, makorin ring finger protein 2 L homeolog antikoerper, makorin-2 antikoerper, makorin, ring finger protein, 2 antikoerper, MKRN2 antikoerper, LOC100401355 antikoerper, mkrn2 antikoerper, mkrn2.L antikoerper, Mkrn2 antikoerper

Hintergrund:

Synonyms: HSPC070_ Makorin 2, Makorin ring finger protein 2, Makorin2, Makorin-2 MKRN 2, RING finger protein 62, RNF 62, RNF62, MKRN2_HUMAN, Probable E3 ubiquitin-protein ligase makorin-2, RING finger protein 62.

Background: The Makorins are a family of putative ribonucleoproteins containing two to four C3H zinc fingers that may confer RNA-binding. In addition, they contain a C3HC4 RING zinc finger that allows them to function as E3 ubiquitin ligases. Makorin-2, also known as RNF62, HSPC070 or MKRN2, is a widely expressed, evolutionarily conserved protein with four C3H-type zinc fingers (three at the N-terminus and one at the C-terminus), one RING-type zinc finger and a cysteine and histidine motif similar to that found in Makorin-1. In Xenopus, Makorin-2 functions, via PI 3-kinase/Akt signaling, as a negative regulator of neurogenesis. In humans, Makorin-2 is overexpressed in various cancer cell lines, suggesting a possible role of Makorin-2 in tumor progression. In addition, Makorin-2 is co-expressed with Raf-1 in the same tissues and cell lines.

Gen-ID: 23609