C17orf49 Antikörper

Produktnummer ABIN1386013

Produktdetails anti-C17orf49 Antikörper

Target: C17orf49 (Chromosome 17 Open Reading Frame 49 (C17orf49))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser C17orf49 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human C17orf49

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu C17orf49

Target: C17orf49 (Chromosome 17 Open Reading Frame 49 (C17orf49))

Andere Bezeichnung: C17orf49 (C17orf49 Produkte)

Synonyme: BAP18 antikoerper, HEPIS antikoerper, bap18 antikoerper, C17orf49 antikoerper, MGC145240 antikoerper, 1110020A23Rik antikoerper, AL033328 antikoerper, AU045833 antikoerper, Bap18 antikoerper, RP23-198E14.7 antikoerper, chromosome 17 open reading frame 49 antikoerper, chromosome 17 open reading frame 49 S homeolog antikoerper, chromosome 19 open reading frame, human C17orf49 antikoerper, chromosome 16 open reading frame, human C17orf49 antikoerper, RIKEN cDNA 0610010K14 gene antikoerper, similar to RIKEN cDNA 1110020A23 antikoerper, C17orf49 antikoerper, c17orf49.S antikoerper, C19H17orf49 antikoerper, C16H17orf49 antikoerper, c17orf49 antikoerper, 0610010K14Rik antikoerper, RGD1308134 antikoerper

Hintergrund:

Synonyms: Bap18, BAP18_HUMAN, BPTF-associated protein of 18 kDa, Chromatin complexes subunit BAP18, Chromosome 17 open reading frame 49, Hypothetical protein LOC124944, MGC49942, Uncharacterized potential DNA binding protein C17orf49.

Background: C17orf49 is a 172 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5 % of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.

Gen-ID: 124944