EP400 Antikörper (AA 1051-1250)

Produktnummer ABIN1386134

Produktdetails anti-EP400 Antikörper

Target: EP400 (E1A Binding Protein P400 (EP400))

Bindungsspezifität: AA 1051-1250

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EP400 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Homologie: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human p400

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu EP400

Target: EP400 (E1A Binding Protein P400 (EP400))

Andere Bezeichnung: P400 (EP400 Produkte)

Synonyme: CAGH32 antikoerper, P400 antikoerper, TNRC12 antikoerper, 1700020J09Rik antikoerper, AU023439 antikoerper, mDomino antikoerper, mKIAA1498 antikoerper, p400 antikoerper, E1A binding protein p400 antikoerper, EP400 N-terminal-like protein antikoerper, helicase domino antikoerper, E1a binding protein P400 antikoerper, EP400 antikoerper, Ep400 antikoerper, LOC738562 antikoerper, LOC5570719 antikoerper, CpipJ_CPIJ007689 antikoerper, CpipJ_CPIJ007688 antikoerper, CpipJ_CPIJ007686 antikoerper, CpipJ_CPIJ008061 antikoerper

Hintergrund:

Synonyms: CAG repeat protein 32, CAGH32, DKFZP434I225, Domino homolog, E1A binding protein p400, EP 400, EP400, FLJ42018, FLJ45115, hDomino, KIAA1498, KIAA1818, p400 kDa SWI2/SNF2 related protein, P400 SWI2/SNF2-related protein, TNRC12, Trinucleotide repeat containing 12, Trinucleotide repeat containing gene 12 protein, EP400_HUMAN.

Background: NuAR is a multi-protein histone acetyltransferase complex that functions to acetylate the nucleosomal Histones H4 and H2A, thereby activating transcription of select target genes. p400, also known as EP400 (E1A binding protein p400) or mDomino, localizes to the nucleus and is a component of the NuAR complex. Expressed in brain, liver, thymus, lung, spleen, colon and kidney, p400 regulates the transcriptional activity of proteins such as MZF-1 and contributes to the ATPase and helicase activities of NuA4. p400 is a SWI2/ SNF2-related protein that can interact with the adenovirus oncoprotein E1A, thus activating the proapoptotic activity of E1A. The ability of p400 to regulate transcriptional and apoptotic activity suggests that the NuAR complex may be a crucial component of cell proliferation, transformation and, possibly, carcinogenesis. Five isoforms of p400 exist due to alternative splicing events.

Gen-ID: 57634

Pathways: Chromatin Binding