Glutathione Synthetase Antikörper (AA 81-160)

Produktnummer ABIN1386180

Produktdetails anti-Glutathione Synthetase Antikörper

Target: Glutathione Synthetase (GSS)

Bindungsspezifität: AA 81-160

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Glutathione Synthetase Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Sheep,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Glutathione Syntase

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu Glutathione Synthetase

Target: Glutathione Synthetase (GSS)

Andere Bezeichnung: GSS/Glutathione Synthetase (GSS Produkte)

Synonyme: PRNP antikoerper, 6835 antikoerper, CG32497 antikoerper, CG33065 antikoerper, CG6835 antikoerper, Dmel\\CG6835 antikoerper, F21A20.90 antikoerper, F21A20_90 antikoerper, GLUTATHIONE SYNTHETASE antikoerper, GSHB antikoerper, glutathione synthetase 2 antikoerper, GSHS antikoerper, AI314904 antikoerper, GS-A/GS-B antikoerper, gssls-a antikoerper, glutathione synthetase antikoerper, Glutathione Synthetase antikoerper, glutathione synthetase 2 antikoerper, glutathione synthetase L homeolog antikoerper, GSS antikoerper, GSH2 antikoerper, Tola_1250 antikoerper, PC1_3711 antikoerper, Dd586_3633 antikoerper, Kvar_0701 antikoerper, Alvin_0197 antikoerper, Nhal_0215 antikoerper, BC1002_0254 antikoerper, Cseg_4017 antikoerper, Snov_3844 antikoerper, Aazo_1904 antikoerper, M301_2613 antikoerper, Bresu_0515 antikoerper, Isop_1460 antikoerper, Marme_4020 antikoerper, Thicy_0325 antikoerper, Sinme_3668 antikoerper, Mesop_0757 antikoerper, Gss antikoerper, gss.L antikoerper

Hintergrund:

Synonyms: Glutathione synthase; GSH S; GSH synthetase; GSH-S; GSHB_HUMAN; GSHS; GSS antibodyMGC14098; OTTHUMP00000030711.

Background: GSS (Glutathione synthetase) is a 474 amino acid protein encoded by the gene located at human chromosome 20q11.2. GSS consists of three loops projecting from an antiparallel -sheet, a parallel -sheet and a lid of anti-parallel sheets, which provide access to the ATP-binding site. Although Southern blot and gene analysis suggest that GSS may be the only member of a unique family, the crystal structure indicates that GSS belongs to the ATP-GRASP superfamily. GSS is expressed in hemocytes and nucleated cells, including the brain. GSS occurs as a homodimer. There are two steps in the production of Glutathione, begining with GSS (Glutathione synthetase) is a 474 amino acid protein encoded by the gene located at human chromosome 20q11.2. GSS consists of three loops projecting from an antiparallel -sheet, a parallel -sheet and a lid of anti-parallel sheets, which provide access to the ATP-binding site. Although Southern blot and gene analysis suggest that GSS may be the only member of a unique family, the crystal structure indicates that GSS belongs to the ATP-GRASP superfamily. GSS is expressed in hemocytes and nucleated cells, including the brain. GSS occurs as a homodimer. There are two steps in the production of Glutathione, begining with ©-GCS and ending with GSS. In an ATP-dependent reaction, GSS produces Glutathione from ©-glutamylcysteine and glycine precursors. Partial hepatectomy, diethyl maleate, buthionine sulfoximine, tert-butylhaydroquinone and thioacetamide increase the ex-pression of GSS, which causes an increase in Glutathione levels. An inherited autosomal recessive disorder, 5-oxoprolinuria (pyroglutamic aciduria), is caused by GSS deficiencies, which leads to central nervous system damage, hemolytic anemia, metabolic acidosis and urinary excretion of 5-oxoproline. A missense mutation in the gene encoding GSS leads to a GSS deficiency restricted to erythrocytes, which causes only hemolytic anemia.-GCS and ending with GSS.

Pathways: Warburg Effekt