AFG3L2 Antikörper (AA 531-600)

Produktnummer ABIN1386200

Produktdetails anti-AFG3L2 Antikörper

Target: AFG3L2 (AFG3-Like Protein 2 (AFG3L2))

Bindungsspezifität: AA 531-600

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AFG3L2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Maus, Ratte

Homologie: Human,Dog,Cow,Sheep,Pig,Horse,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human AFG3L2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu AFG3L2

Target: AFG3L2 (AFG3-Like Protein 2 (AFG3L2))

Andere Bezeichnung: SCA28/AFG3L2 (AFG3L2 Produkte)

Synonyme: MGC147390 antikoerper, si:ch211-12e1.4 antikoerper, SCA28 antikoerper, SPAX5 antikoerper, 2310036I02Rik antikoerper, AW260507 antikoerper, Emv66 antikoerper, par antikoerper, AFG3 like matrix AAA peptidase subunit 2 antikoerper, AFG3-like protein 2 antikoerper, AFG3 ATPase family gene 3-like 2 (S. cerevisiae) antikoerper, AFG3-like AAA ATPase 2 antikoerper, AFG3-like AAA ATPase 2 L homeolog antikoerper, AFG3L2 antikoerper, LOC578526 antikoerper, afg3l2 antikoerper, afg3l2.L antikoerper, Afg3l2 antikoerper

Hintergrund:

Synonyms: AFG3 ATPase family gene 3, yeast like 2, AFG3 ATPase family gene 3 like 2 yeast, AFG3 ATPase family gene 3 like 2, AFG3 like protein 2, ATPase family gene 3 like 2, ATPase family gene 3 yeast, FLJ25993, Paraplegin like protein, SCA28, Spinocerebellar ataxia 28, AFG32_HUMAN .

Background: AFG3L2 is a multi-pass membrane metalloprotease that contains one AAA (ATPase associated with diverse cellular activities) domain, a zinc-dependent binding motif, an RNA-binding region and an ATP/GTP binding site. Localizing to the mitochondrial membrane, AFG3L2 is ubiquitously expressed with highest expression levels in skeletal muscle and heart. AFG3L2 shares 69 % similarity with the yeast Afg3 protein and 49 % similarity with Paraplegin, a protein of mitochondria that is thought to be involved in signal transduction and chaperone-like activities. In mitochondria, AFG3L2 forms a complex with Paraplegin that is believed to regulate essential protein quality control. Mutations in the gene encoding either one of these proteins can result in hereditary spastic paraplegia, a degenerative spinal cord disorder that is characterized by muscle spasms, stiffness in the legs and, in some cases, incontinence.

Pathways: Skeletal Muscle Fiber Development