JARID2 Antikörper (AA 301-400)

Produktnummer ABIN1386206

Produktdetails anti-JARID2 Antikörper

Target: JARID2 (Jumonji, AT Rich Interactive Domain 2 (JARID2))

Bindungsspezifität: AA 301-400

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser JARID2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Ratte

Homologie: Mouse,Dog,Cow,Sheep,Pig,Horse,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Jarid2/Jumonji

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu JARID2

Target: JARID2 (Jumonji, AT Rich Interactive Domain 2 (JARID2))

Andere Bezeichnung: Jarid2/Jumonji (JARID2 Produkte)

Synonyme: JMJ antikoerper, Jmj antikoerper, jumonji antikoerper, JARID2 antikoerper, jarid2 antikoerper, jmj antikoerper, si:dkey-211c3.1 antikoerper, Jumonji antikoerper, jarid2-a antikoerper, jarid2-b antikoerper, jarid2.S antikoerper, jarid2b antikoerper, jumonji and AT-rich interaction domain containing 2 antikoerper, jumonji, AT rich interactive domain 2 antikoerper, jumonji, AT rich interactive domain 2a antikoerper, jumonji, AT rich interactive domain 2b antikoerper, jumonji and AT-rich interaction domain containing 2 L homeolog antikoerper, JARID2 antikoerper, Jarid2 antikoerper, jarid2a antikoerper, jarid2 antikoerper, jarid2b antikoerper, jarid2.L antikoerper

Hintergrund:

Synonyms: JMJ, Protein Jumonji, Jumonji/ARID domain-containing protein 2, JARID2

Background: Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.

Gen-ID: 3720

UniProt: Q92833

Pathways: Chromatin Binding