Bestrophin 2 Antikörper (AA 101-200)

Produktnummer ABIN1386381

Produktdetails anti-Bestrophin 2 Antikörper

Target: Bestrophin 2 (BEST2)

Bindungsspezifität: AA 101-200

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Bestrophin 2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Bestrophin 2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu Bestrophin 2

Target: Bestrophin 2 (BEST2)

Andere Bezeichnung: Bestrophin 2 (BEST2 Produkte)

Synonyme: VMD2L1 antikoerper, CG10173 antikoerper, Dmel\\CG10173 antikoerper, dbest2 antikoerper, Vmd2l1 antikoerper, best2 antikoerper, vmd2l1 antikoerper, MGC53680 antikoerper, MGC132361 antikoerper, Best2 antikoerper, GB16861 antikoerper, si:dkey-121b10.4 antikoerper, MGC75942 antikoerper, best2-a antikoerper, best2-b antikoerper, variant 2 antikoerper, bestrophin 2 antikoerper, Bestrophin 2 antikoerper, bestrophin 2 L homeolog antikoerper, uncharacterized LOC408898 antikoerper, bestrophin 2 S homeolog antikoerper, BEST2 antikoerper, Best2 antikoerper, best2.L antikoerper, LOC408898 antikoerper, best2 antikoerper, best2.S antikoerper

Hintergrund:

Synonyms: BEST 2, Best disease Bestrophin, BEST2, Bestrophin2, FLJ20132, Vitellorm macular dystrophy 2 homolog, Vitellorm macular dystrophy 2 like 1, Vitellorm macular dystrophy 2 like protein 1, Vitellorm macular dystrophy, VMD2, VMD2 like gene 1, VMD2L1, BEST2_HUMAN.

Background: The Bestrophins are a newly described family of anion channels unrelated in primary sequence to any previously characterized channel proteins. Bestrophins were originally defined as a family of over 20 related sequences of the C. elegans. The first mammalian Bestrophin was identified as the vitelliform macular dystrophy (VMD), 1 also known as Best disease. Three more members of the bestrophin family members were cloned and indentified recently, Bestrophin 2, 3 and 4. RT PCR analyses revealed tissue restricted expression of the three genes with both Bestrophin 1 and Bestrophin 2 are abundantly transcribed in colon. Functionally the bestrophines oligomerise to form tetramers and pentamers in order to act as calcium sensitive chloride channels. It has been shown that Bestrophin interacts with beta catalytic subunit of protein phosphatase 2A (PP2Ac). Such protein protein interaction between Bestrophin and PP2Ac and the structural subunit of PP2A, PR65, was confirmed by reciprocal immunoprecipitation. The interaction between PP2Ac and the Bestrophin takes place near the carboxy terminal end of the protein.