SHANK3 Antikörper (AA 1151-1250)
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- Target Alle SHANK3 Antikörper anzeigen
- SHANK3 (SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3))
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Bindungsspezifität
- AA 1151-1250
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Reaktivität
- Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser SHANK3 Antikörper ist unkonjugiert
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Applikation
- Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Kreuzreaktivität
- Ratte
- Homologie
- Human,Mouse,Dog,Cow,Pig,Horse
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human SHANK3
- Isotyp
- IgG
- Top Product
- Discover our top product SHANK3 Primärantikörper
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- Applikationshinweise
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ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- SHANK3 (SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3))
- Andere Bezeichnung
- SHANK3 (SHANK3 Produkte)
- Synonyme
- DEL22q13.3 antikoerper, PROSAP2 antikoerper, PSAP2 antikoerper, SCZD15 antikoerper, SPANK-2 antikoerper, Prosap2 antikoerper, AI841104 antikoerper, Shank3b antikoerper, SH3 and multiple ankyrin repeat domains 3 antikoerper, SH3 and multiple ankyrin repeat domains protein 3 antikoerper, SHANK3 antikoerper, shank3 antikoerper, Shank3 antikoerper
- Hintergrund
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Synonyms: PSAP2, SCZD15, PROSAP2, SPANK-2, DEL22q13.3, SH3 and multiple ankyrin repeat domains protein 3, Shank3, Proline-rich synapse-associated protein 2, KIAA1650
Background: Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation.
- Gen-ID
- 85358
- UniProt
- Q9BYB0
- Pathways
- Synaptic Membrane, Tube Formation, Regulation of long-term Neuronal Synaptic Plasticity
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