SLC51B Antikörper (AA 1-35)

Produktnummer ABIN1386750

Produktdetails anti-SLC51B Antikörper

Target: SLC51B (OSTBETA) (Organic Solute Transporter beta (OSTBETA))

Bindungsspezifität: AA 1-35

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SLC51B Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Maus

Homologie: Human,Rat

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human OST-beta

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-SLC51B Antikörper (ABIN1386750)

Stipanuk, Jurkowska, Niewiadomski, Mazor, Roman, Hirschberger: "Identification of Taurine-Responsive Genes in Murine Liver Using the Cdo1-Null Mouse Model." in: Advances in experimental medicine and biology, Vol. 975, pp. 475-495, (2017) (PubMed).

Details zu SLC51B

Target: SLC51B (OSTBETA) (Organic Solute Transporter beta (OSTBETA))

Andere Bezeichnung: OST-beta (OSTBETA Produkte)

Hintergrund:

Synonyms: organic solute transporter beta Ostbeta, Organic solute transporter subunit beta, Ostbeta, Ost beta, OST-beta, OSTB, OSTB_HUMAN.

Background: The heteromeric transporter OST Alpha/OST Beta facilitates the transport of bile and other steroid solutes across the basolateral epithelial cell membrane of intestine, liver, testis, kidney and adrenal gland. OST Alpha/OST Beta expression is induced by bile acids through ligand-dependent transactivation of their genes by FXR (Farnesoid X-activated receptor). This genetic regulation suggests that in response to changes in intracellular bile acid levels, bile acids adjust the rate of their own efflux from enterocytes. OST Beta is a 128 amino acid single-pass transmembrane protein that requires OST Alpha to localize to the plasma membrane. Coexpression of OST Alpha and OST Beta is also required to convert the OST Alpha subunit to a mature glycosylated endoglycosidase H-resistant form, suggesting that co-expression facilitates trafficking of OST Alpha through the golgi apparatus. Though widely expressed, OST Beta is present at highest levels in ileum.

Gen-ID: 123264

Pathways: Regulation of Carbohydrate Metabolic Process