DR1 Antikörper

Produktnummer ABIN1386906

Produktdetails anti-DR1 Antikörper

Target: DR1 (TATA-Binding Protein-Associated Phosphoprotein (DR1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DR1 protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu DR1

Target: DR1 (TATA-Binding Protein-Associated Phosphoprotein (DR1))

Andere Bezeichnung: DR1 Protein (DR1 Produkte)

Synonyme: BG:DS00929.3 antikoerper, CG4185 antikoerper, Dmel\\CG4185 antikoerper, Dr1 antikoerper, NC2 beta antikoerper, Nc2b antikoerper, dDr1 antikoerper, dNC2 antikoerper, wu:fj15f04 antikoerper, zgc:152914 antikoerper, 1700121L09Rik antikoerper, Dr1l antikoerper, NC2 antikoerper, NC2beta antikoerper, NC2-BETA antikoerper, Negative Cofactor 2beta antikoerper, TATA-BINDING PROTEIN-ASSOCIATED PHOSPHOPROTEIN antikoerper, TATA-binding protein-associated phosphoprotein antikoerper, putative tata-binding protein-associated phosphoprotein antikoerper, down-regulator of transcription 1 antikoerper, down-regulator of transcription 1, TBP-binding (negative cofactor 2) antikoerper, NC2beta antikoerper, ECU11_0730 antikoerper, EDI_229030 antikoerper, PTRG_08168 antikoerper, Smp_160150 antikoerper, EBI_26279 antikoerper, EBI_23074 antikoerper, VDBG_02216 antikoerper, dr1 antikoerper, Dr1 antikoerper, DR1 antikoerper

Hintergrund:

Synonyms: Dr1 protein; NC2; Negative cofactor 2 beta; Down regulator of transcription 1; Down regulator of transcription 1 TBP binding; Down-regulator of transcription 1; DR 1; Dr1; NC 2; NC2 beta; NC2-beta; NC2B_HUMAN; Negative co factor 2; Negative cofactor 2; Negative cofactor 2-beta; Protein Dr1; TATA binding protein associated phosphoprotein; TATA-binding protein-associated phosphoprotein.

Background: DR1, also known as NC2 (negative cofactor 2 subunit ), is a TFIID (TATA box-binding protein)-associated protein. DR1 localizes to the nucleus and contains an N-terminal histone fold motif, a TFIID-binding domain and an alanine and glutamine rich region. Via its histone fold motif, DR1 forms a heterodimer with NC2å (DRAP1) to comprise the conserved eukaryotic complex, NC2 (negative cofactor 2). The NC2 complex can both positively and negatively regulate transcription by RNA Pol II. More specifically, NC2 acts as a repressor of TATA-dependent transcription and acts as an activator for DPE-dependent transcription. NC2 represses RNA Pol II transcription by binding to TFIID and inhibiting association of the transcription factors TFIIA and TFIIB. NC2 activity is regulated by phosphorylation. Both subunits, NC2å and DR1, are phosphorylated in vivo.

Gen-ID: 10589