COPS4 Antikörper

Produktnummer ABIN1386938

Produktdetails anti-COPS4 Antikörper

Target: COPS4 (COP9 Signalosome Subunit 4 (COPS4))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser COPS4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human COPS4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu COPS4

Target: COPS4 (COP9 Signalosome Subunit 4 (COPS4))

Andere Bezeichnung: COPS4 (COPS4 Produkte)

Synonyme: CG8725 antikoerper, CH4 antikoerper, Cops4 antikoerper, Csn4 antikoerper, DCH4 antikoerper, Dch4 antikoerper, Dmel\\CG8725 antikoerper, csn4 antikoerper, l(2)k08018 antikoerper, COPS4 antikoerper, SGN4 antikoerper, DKFZp459H0324 antikoerper, AW208976 antikoerper, D5Ertd774e antikoerper, fc90c08 antikoerper, wu:fc90c08 antikoerper, zgc:77137 antikoerper, ATS4 antikoerper, CONSTITUTIVE PHOTOMORPHOGENIC 14 antikoerper, CONSTITUTIVE PHOTOMORPHOGENIC 8 antikoerper, COP14 antikoerper, COP9 SIGNALOSOME SUBUNIT 4 antikoerper, CSN4 antikoerper, EMB134 antikoerper, EMBRYO DEFECTIVE 134 antikoerper, FUS4 antikoerper, FUS8 antikoerper, FUSCA 4 antikoerper, FUSCA 8 antikoerper, MBD2.17 antikoerper, MBD2_17 antikoerper, COS41.8 antikoerper, COP9 signalosome subunit 4 antikoerper, COP9 signalosome complex subunit 4 antikoerper, COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) antikoerper, Proteasome component (PCI) domain protein antikoerper, COP9 signalosome subunit 4 L homeolog antikoerper, CSN4 antikoerper, COPS4 antikoerper, CpipJ_CPIJ000966 antikoerper, csn4 antikoerper, Cops4 antikoerper, cops4 antikoerper, COP8 antikoerper, cops4.L antikoerper, csn-4 antikoerper

Hintergrund:

Synonyms: CH4, COP9 constitutive photomorphogenic homolog subunit 4, COP9 complex homolog subunit 4, COP9 complex S4, COP9 constitutive photomorphogenic homolog subunit 4, COP9 signalosome complex subunit 4, COP9 signalosome subunit 4, COPS4, CSN complex subunit 4, CSN4, CSN4 SCHPO, CSN4_HUMAN, DCH4, JAB1 containing signalosome subunit 4, JAB1-containing signalosome subunit 4, MGC94896, SGN4, Signalosome subunit 4.

Background: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Gen-ID: 51138

Pathways: Zellzyklus