SASS6 Antikörper

Produktnummer ABIN1387012

Produktdetails anti-SASS6 Antikörper

Target: SASS6 (Spindle Assembly 6 Homolog (SASS6))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SASS6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SASS6

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu SASS6

Target: SASS6 (Spindle Assembly 6 Homolog (SASS6))

Andere Bezeichnung: SASS6 (SASS6 Produkte)

Synonyme: SAS-6 antikoerper, SAS6 antikoerper, 2810453L12Rik antikoerper, RGD1306255 antikoerper, CG15524 antikoerper, DSAS-6 antikoerper, DSas-6 antikoerper, DSas6 antikoerper, Dmel\\CG15524 antikoerper, Dsas6 antikoerper, Sas-6 antikoerper, Sas6 antikoerper, dsas-6 antikoerper, sas6 antikoerper, wu:fb98c12 antikoerper, zgc:55668 antikoerper, SASS6 antikoerper, sass6.2 antikoerper, SAS-6 centriolar assembly protein antikoerper, Spindle assembly abnormal 6 antikoerper, spindle assembly 6 homolog L homeolog antikoerper, SAS-6 centriolar assembly protein L homeolog antikoerper, SASS6 antikoerper, Sass6 antikoerper, Sas-6 antikoerper, sass6.L antikoerper, sass6 antikoerper, sass6.2.L antikoerper

Hintergrund:

Synonyms: HsSAS 6, HsSAS6, MGC119440, SAS 6, SAS6, SASS 6, Spindle assembly 6 homolog C. elegans, Spindle assembly 6 homolog, Spindle assembly abnormal protein 6 homolog, PJA2_HUMAN.

Background: SAS-6 (spindle assembly abnormal protein 6 homolog, HsSAS-6) is a 657 amino acid protein encoded by the human gene SAS6. SAS-6 is a component of the centrosome that contains one PISA (present in SAS-6) domain. LK4, SAS-6, CPAP and other centriole related proteins are required at different stages of procentriole formation and were associated with different centriolar structures. SAS-6 associates only transiently with nascent procentrioles, whereas CEP135 and CPAP form a core structure within the proximal lumen of both parental and nascent centrioles. SAS-6 is necessary for procentriole formation in human cell lines and is localized asymmetrically next to the centriole at the onset of procentriole formation. SAS-6 levels oscillate during the cell cycle, it is degraded in mitosis starting at anaphase, and it accumulates again at the end of the following G1 phase. The anaphase-promoting complex targets SAS-6 for degradation by the 26S Proteasome, and a KEN box in the C-terminus of SAS-6 is necessary for its degradation. Increased SAS-6 levels promoted the formation of multiple procentrioles forming next to a single centriole.

Gen-ID: 163786