MARCH8 Antikörper

Produktnummer ABIN1387037

Produktdetails anti-MARCH8 Antikörper

Target: MARCH8 (Membrane-Associated Ring Finger (C3HC4) 8, E3 Ubiquitin Protein Ligase (MARCH8))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MARCH8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MARCH8

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu MARCH8

Target: MARCH8 (Membrane-Associated Ring Finger (C3HC4) 8, E3 Ubiquitin Protein Ligase (MARCH8))

Andere Bezeichnung: MARCH8 (MARCH8 Produkte)

Synonyme: MARCH-VIII antikoerper, MIR antikoerper, RNF178 antikoerper, c-MIR antikoerper, zgc:171495 antikoerper, 1300017E09Rik antikoerper, Mir antikoerper, Mar-08 antikoerper, MARCH8 antikoerper, membrane associated ring-CH-type finger 8 antikoerper, membrane-associated ring finger (C3HC4) 8 antikoerper, membrane associated ring-CH-type finger 8 L homeolog antikoerper, MARCH8 antikoerper, march8 antikoerper, March8 antikoerper, march8.L antikoerper

Hintergrund:

Synonyms: c MIR, c-MIR, Cellular modulator of immune recognition, E3 ubiquitin protein ligase MARCH8, E3 ubiquitin-protein ligase MARCH8, MARCH 8, MARCH VIII, MARCH-VIII, MARCH8, MARH8_HUMAN, Membrane associated RING CH protein VIII, Membrane associated ring finger C3HC4 8, Membrane associated RING finger protein 8, Membrane-associated RING finger protein 8, Membrane-associated RING-CH protein VIII, MIR, RING finger protein 178, RNF178.

Background: The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. MARCH8 (membrane-associated ring finger (C3HC4) 8), also known as MIR or RNF178 (RING finger protein 178), is a 291 amino acid multi-pass membrane protein that localizes to vesicle membranes and contains one RING-CH-type zinc finger. Expressed in a variety of tissues, including immature dendritic cells, MARCH8 functions as an E3 ubiquitin ligase that is thought to regulate immune responses by promoting the ubiquitination and subsequent degradation of target proteins, such as B7-2 and CD71.

Gen-ID: 220972