MARCH9 Antikörper

Produktnummer ABIN1387038

Produktdetails anti-MARCH9 Antikörper

Target: MARCH9 (Membrane-Associated Ring Finger (C3HC4) 9 (MARCH9))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MARCH9 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MARCH9

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu MARCH9

Target: MARCH9 (Membrane-Associated Ring Finger (C3HC4) 9 (MARCH9))

Andere Bezeichnung: MARCH9 (MARCH9 Produkte)

Synonyme: Rnf179 antikoerper, March-IX antikoerper, MARCH-IX antikoerper, RNF179 antikoerper, AI608492 antikoerper, BC019560 antikoerper, membrane associated ring-CH-type finger 9 antikoerper, membrane associated ring-CH-type finger 9 S homeolog antikoerper, membrane-associated ring finger (C3HC4) 9 antikoerper, March9 antikoerper, march9.S antikoerper, MARCH9 antikoerper, march9 antikoerper

Hintergrund:

Synonyms: E3 ubiquitin protein ligase MARCH9, MARCH IX, Membrane associated RING CH protein IX, membrane associated ring finger C3HC4 9, Membrane associated RING finger protein 9, RING finger protein 179, RNF179, MARH9_HUMAN.

Background: Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). MARCH9 (membrane-associated ring finger (C3HC4) 9), also known as RNF179, is a 346 amino acid multi-pass membrane protein that localizes to the golgi apparatus and contains one RING-CH-type zinc finger. Expressed ubiquitously, MARCH9 exists as a homodimer and functions as an E3 ubiquitin-protein ligase that accepts a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and is thought to promote the degradation of target proteins, such as CD4 and MHC-I. Multiple isoforms of MARCH9 exist due to alternative splicing events.

Gen-ID: 92979