MID1 Antikörper (AA 200-250)

Produktnummer ABIN1387054

Produktdetails anti-MID1 Antikörper

Target: MID1 (Midline 1 (MID1))

Bindungsspezifität: AA 200-250

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MID1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Midline-1/RNF59

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu MID1

Target: MID1 (Midline 1 (MID1))

Andere Bezeichnung: Midline-1 (MID1 Produkte)

Synonyme: BBBG1 antikoerper, FXY antikoerper, GBBB1 antikoerper, MIDIN antikoerper, OGS1 antikoerper, OS antikoerper, OSX antikoerper, RNF59 antikoerper, TRIM18 antikoerper, XPRF antikoerper, ZNFXY antikoerper, 61B3-R antikoerper, DXHXS1141 antikoerper, Fxy antikoerper, Trim18 antikoerper, Midline1 antikoerper, bbbg1 antikoerper, fxy antikoerper, gbbb1 antikoerper, midin antikoerper, ogs1 antikoerper, osx antikoerper, rnf59 antikoerper, trim18 antikoerper, xprf antikoerper, znfxy antikoerper, midline 1 antikoerper, midline 1 L homeolog antikoerper, MID1 antikoerper, Mid1 antikoerper, mid1 antikoerper, mid1.L antikoerper

Hintergrund:

Synonyms: BBBG1, Finger on X and Y mouse homolog of antibody, FXY, GBBB1, MID-1, Mid1, Midin, Midline 1 Opitz/BBB syndrome, Midline 1, Midline 1 ring finger, Midline 1 RING finger protein, Midline-1, Midline1, OGS1, OSX, Putative transcription factor XPRF, RING finger protein 59, RNF59, TRI18, TRI18_HUMAN, TRIM18, Tripartite mot containing protein 18, Tripartite mot protein TRIM18, Tripartite mot-containing protein 18, XPRF, Zinc finger X and Y antibody, ZNFXY.

Background: Midline-1 (Tripartite motif-containing protein 18, Putative transcription factor XPRF, RING finger protein 59) is a 667 amino acid protein encoded by the human gene MID1. Midline-1 belongs to the TRIM/RBCC family and contains two B box-type zinc fingers, one B30.2/SPRY domain, one COS domain, one fibronectin type-III domain and one RING-type zinc finger. Midline-1 is believed to have E3 ubiquitin ligase activity which targets the catalytic subunit of protein phosphatase 2 for degradation. It is a cytoplasmic protein found as a homodimer or heterodimer with Midline-2. It also interacts with IGBP1 (Lymphocyte signaling protein A4). Defects in MID1 are the cause of Opitz syndrome type I (OS-I). OS-I is an X-linked recessive disorder characterized by hypertelorism, genital-urinary defects such as hypospadias in males and splayed labia in females, lip-palate-laryngotracheal clefts, imperforate anus, developmental delay and congenital heart defects. OS-I mutations produce proteins with a decreased affinity for microtubules.

Gen-ID: 4281

UniProt: O15344