TMIGD1 Antikörper (AA 160-200)

Produktnummer ABIN1387070

Produktdetails anti-TMIGD1 Antikörper

Target: TMIGD1 (Transmembrane and Immunoglobulin Domain Containing 1 (TMIGD1))

Bindungsspezifität: AA 160-200

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TMIGD1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TMIGD1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu TMIGD1

Target: TMIGD1 (Transmembrane and Immunoglobulin Domain Containing 1 (TMIGD1))

Andere Bezeichnung: TMIGD1 (TMIGD1 Produkte)

Synonyme: RGD1307444 antikoerper, Tmigd antikoerper, TMIGD antikoerper, UNQ9372 antikoerper, 2010002A20Rik antikoerper, transmembrane and immunoglobulin domain containing 1 antikoerper, Tmigd1 antikoerper, TMIGD1 antikoerper

Hintergrund:

Synonyms: TMIGD, UNQ9372, Transmembrane and immunoglobulin domain-containing protein 1, TMIGD1, UNQ9372/PRO34164

Background: Chromosome 17 makes up over 2.5 % of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dub? syndrome and Canavan disease are also associated with chromosome 17.

Gen-ID: 388364

UniProt: Q6UXZ0