NFAT5 Antikörper (pSer1197)

Produktnummer ABIN1387082

Produktdetails anti-NFAT5 Antikörper

Target: NFAT5 (Nuclear Factor of Activated T-Cells 5, Tonicity-Responsive (NFAT5))

Bindungsspezifität: pSer1197

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NFAT5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human NFAT5 around the phosphorylation site of Ser1197

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu NFAT5

Target: NFAT5 (Nuclear Factor of Activated T-Cells 5, Tonicity-Responsive (NFAT5))

Andere Bezeichnung: NFAT5 (NFAT5 Produkte)

Synonyme: zgc:63502 antikoerper, wu:fi46f11 antikoerper, TonEBP antikoerper, NFAT5 antikoerper, nfatz antikoerper, orebp antikoerper, nf-at5 antikoerper, nfatl1 antikoerper, tonebp antikoerper, DKFZp469P1514 antikoerper, AI225870 antikoerper, B130038B15Rik antikoerper, CAG-8 antikoerper, CAG80 antikoerper, NFATL1 antikoerper, OREBP antikoerper, mKIAA0827 antikoerper, NF-AT5 antikoerper, NFATZ antikoerper, TONEBP antikoerper, Nfat antikoerper, nuclear factor of activated T-cells 5 antikoerper, nuclear factor of activated T-cells 5, tonicity-responsive a antikoerper, nuclear factor of activated T-cells 5, tonicity-responsive S homeolog antikoerper, nuclear factor of activated T-cells 5, tonicity-responsive antikoerper, nuclear factor of activated T cells 5 antikoerper, NFAT5 antikoerper, nfat5a antikoerper, nfat5.S antikoerper, nfat5 antikoerper, Nfat5 antikoerper

Hintergrund:

Synonyms: NFAT5 phospho S1197, p-NFAT5phospho S1197, Glutamine rich protein H65, KIAA0827, NF AT5, NF-AT5, NFAT 5, NFAT L1, NFAT like protein 1, NFAT5, NFAT5_HUMAN, NFATL 1, NFATL1, NFATZ, Nuclear factor of activated T cells 5, Nuclear factor of activated T cells 5 tonicity responsive, Nuclear factor of activated T cells, Nuclear factor of activated T-cells 5, OREBP, Osmotic response element binding protein, T cell transcription factor NFAT 5, T cell transcription factor NFAT5, T-cell transcription factor NFAT5, TonE binding protein, TonE-binding protein , TonEBP, Tonicity responsive enhancer binding protein, Tonicity-responsive enhancer-binding protein.

Background: Members of the NFAT (nuclear factor of activated T cells) family of transcription factors are related to NFkB/Rel proteins and form cooperative complexes with the AP-1 proteins, Fos and Jun, on DNA to regulate cytokine expression in T cells. NFAT proteins are widely expressed and alternatively modified to generate splice variants, and they are localized to both the cytosol (NFATc) and to the nucleus (NFATn). NFAT1, NFAT2, and NFAT4 are predominantly expressed in immune cells, and NFAT2 and NFAT3 are expressed at high levels in cardiac tissues. In addition to activating cytokine gene transcription, NFAT2 is also implicated in cardiac valve development, and NFAT3 is involved in cardiac hypertrophy. NFAT5 is detected in both immune and nonimmune cells and, like other NFAT proteins, contains a highly conserved Rel-like binding domain that mediates NFAT proteins associating with specific consensus sequences on DNA. NFAT proteins are activated by increases in intracellular calcium, which leads to the calmodulin-dependent phosphatase, calcineurin, dephosphorylating NFAT proteins. This activating event induces a conformational change in the protein structure that exposes the nuclear localization signal and facilitates the translocation of NFAT proteins from the cytosol into the nucleus.

Gen-ID: 10725

Pathways: RTK Signalweg, WNT Signalweg