ISL2 Antikörper (AA 201-300)

Produktnummer ABIN1387241

Produktdetails anti-ISL2 Antikörper

Target: ISL2 (ISL LIM Homeobox 2 (ISL2))

Bindungsspezifität: AA 201-300

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ISL2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Islet 2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu ISL2

Target: ISL2 (ISL LIM Homeobox 2 (ISL2))

Andere Bezeichnung: Islet 2 (ISL2 Produkte)

Synonyme: ISL-2 antikoerper, isl2 antikoerper, wu:fc29g02 antikoerper, zfIsl-2 antikoerper, ISLET-2 antikoerper, ISL-3 antikoerper, isl3 antikoerper, islet 3 antikoerper, zfIsl-3 antikoerper, zgc:109840 antikoerper, ISL LIM homeobox 2 antikoerper, ISL LIM homeobox 2a antikoerper, ISL LIM homeobox 2b antikoerper, ISL2 antikoerper, Isl2 antikoerper, isl2a antikoerper, isl2b antikoerper

Hintergrund:

Synonyms: Insulin gene enhancer protein ISL 2, Insulin gene enhancer protein ISL-2, Insulin gene enhancer protein ISL2, ISL 2, ISL 2 transcription factor, ISL 2 transcription factor LIM/homeodomain, ISL2, ISL2 transcription factor, ISL2 transcription factor LIM/homeodomain, ISL2_HUMAN, Islet-2, Islet2, FLJ10160.

Background: Islet-2 (insulin gene enhancer protein ISL-2) is a 359 amino acid protein encoded by the human gene ISL2. Islet-2 is a nuclear protein that contains two N-terminal LIM domains, followed by a homeodomain and a serine/ glutamine/threonine-rich C-terminus. Islet-2 is a transcriptional factor that defines subclasses of motor neurons that segregate into columns in the spinal cord and select distinct axon pathways. Islet-1 and Islet-2 are initially ex-pressed by all postmitotic spinal motor neurons prior to diversification of somatic and visceral neuronal fates. Somatic, but not visceral, motor neurons maintain Islet-2 expression at later embryonic stages. An early phase of Islet-2 expression by prospective visceral motor neurons of the sympathetic preganglionic motor column is critical for the emergence of complete visceral motor neuron character. Mutations that reduce or eliminate both Islet-1 and Islet-2 activity will result in pronounced defects in visceral motor neuron generation and eroded somatic motor neuron character.