OSTM1 Antikörper (AA 21-120)

Produktnummer ABIN1387308

Produktdetails anti-OSTM1 Antikörper

Target: OSTM1 (Osteopetrosis Associated Transmembrane Protein 1 (OSTM1))

Bindungsspezifität: AA 21-120

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser OSTM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human OSTM1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu OSTM1

Target: OSTM1 (Osteopetrosis Associated Transmembrane Protein 1 (OSTM1))

Andere Bezeichnung: OSTM1 (OSTM1 Produkte)

Synonyme: MGC145644 antikoerper, si:ch73-257c13.3 antikoerper, GIPN antikoerper, GL antikoerper, OPTB5 antikoerper, 1200002H13Rik antikoerper, HSPC019 antikoerper, gl antikoerper, Gipn antikoerper, OSTM1 antikoerper, osteopetrosis associated transmembrane protein 1 antikoerper, OSTM1 antikoerper, ostm1 antikoerper, Ostm1 antikoerper

Hintergrund:

Synonyms: GL, GIPN, OPTB5, HSPC019, Osteopetrosis-associated transmembrane protein 1, Chloride channel 7 beta subunit, OSTM1, UNQ6098/PRO21201

Background: OSTM1 (osteopetrosis associated transmembrane protein 1), also known as gl (gray-lethal) or HSPC019, is a 338 amino acid single-pass type I membrane protein that is expressed primarily in osteoclasts and melanocytes as well as brain, kidney and spleen. Bone autosomal recessive osteopetrosis (ARO) is the most severe form of hereditary bone disease whose cellular basis is in the osteoclast and is characterized by abnormally dense bone, due to defective resorption of immature bone. ARO is suggested to be caused by mutations in the OSTM1 gene. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Defects in the OSTM1 gene are also the cause of the spontaneous gl mutant, which is responsible for a coat color defect in mice.

Gen-ID: 28962

UniProt: Q86WC4