INTS3 Antikörper (AA 960-998)

Produktnummer ABIN1387357

Produktdetails anti-INTS3 Antikörper

Target: INTS3 (Integrator Complex Subunit 3 (INTS3))

Bindungsspezifität: AA 960-998

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser INTS3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human INTS3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu INTS3

Target: INTS3 (Integrator Complex Subunit 3 (INTS3))

Andere Bezeichnung: INTS3 (INTS3 Produkte)

Synonyme: INTS3 antikoerper, Ints3 antikoerper, NV18802 antikoerper, ACYPI009450 antikoerper, DL3335W antikoerper, FCAALL.260 antikoerper, embryo defective 2739 antikoerper, C1orf193 antikoerper, C1orf60 antikoerper, INT3 antikoerper, SOSS-A antikoerper, C77668 antikoerper, RGD1304593 antikoerper, si:dkey-27c15.2 antikoerper, integrator complex subunit 3 antikoerper, integrator complex subunit 3 L homeolog antikoerper, embryo defective 2739 antikoerper, INTS3 antikoerper, ints3.L antikoerper, CpipJ_CPIJ008133 antikoerper, ints3 antikoerper, Ints3 antikoerper, LOC100168776 antikoerper, emb2739 antikoerper

Hintergrund:

Synonyms: INT3, SOSSA, SOSS-A, C1orf60, C1orf193, Integrator complex subunit 3, SOSS complex subunit A, Sensor of single-strand DNA complex subunit A, Sensor of ssDNA subunit A, INTS3

Background: Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites.

Gen-ID: 65123

UniProt: Q68E01