MSH3 Antikörper (AA 651-750)

Produktnummer ABIN1387468

Produktdetails anti-MSH3 Antikörper

Target: MSH3 (MutS Homolog 3 (MSH3))

Bindungsspezifität: AA 651-750

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MSH3 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat,Dog,Cow,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MSH3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu MSH3

Target: MSH3 (MutS Homolog 3 (MSH3))

Andere Bezeichnung: MSH3 (MSH3 Produkte)

Synonyme: ATMSH3 antikoerper, M7J2.90 antikoerper, M7J2_90 antikoerper, homolog of DNA mismatch repair protein MSH3 antikoerper, DUP antikoerper, MRP1 antikoerper, D13Em1 antikoerper, Rep-3 antikoerper, Rep3 antikoerper, mutS homolog 3 antikoerper, DNA mismatch repair protein MSH3 antikoerper, homolog of DNA mismatch repair protein MSH3 antikoerper, mismatch repair protein antikoerper, MSH3 antikoerper, Msh3 antikoerper

Hintergrund:

Synonyms: Divergent upstream protein, DNA mismatch repair protein, DNA mismatch repair protein Msh 3, DNA mismatch repair protein Msh3, DUC 1, DUC1, DUG, DUP, hMSH3, Mismatch repair protein 1, MRP 1, MRP1, MSH 3, MSH-3, MSH3_HUMAN, MutS homolog 3.

Background: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.

Gen-ID: 4437

Pathways: DNA Reparatur, Production of Molecular Mediator of Immune Response