DLG1 Antikörper (AA 801-904)

Produktnummer ABIN1387516

Produktdetails anti-DLG1 Antikörper

Target: DLG1 (Discs, Large Homolog 1 (DLG1))

Bindungsspezifität: AA 801-904

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DLG1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Homologie: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SAP97

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-DLG1 Antikörper (ABIN1387516)

Lowe, Usowicz, Hodge: "Neuronal overexpression of Alzheimer's disease and Down's syndrome associated DYRK1A/minibrain gene alters motor decline, neurodegeneration and synaptic plasticity in Drosophila." in: Neurobiology of disease, Vol. 125, pp. 107-114, (2019) (PubMed).

Details zu DLG1

Target: DLG1 (Discs, Large Homolog 1 (DLG1))

Andere Bezeichnung: SAP97 (DLG1 Produkte)

Synonyme: DLG1 antikoerper, Dlgh1 antikoerper, SAP97 antikoerper, B130052P05Rik antikoerper, E-dlg/SAP97 antikoerper, SAP-97 antikoerper, mKIAA4187 antikoerper, DLGH1 antikoerper, dJ1061C18.1.1 antikoerper, hdlg antikoerper, discs large MAGUK scaffold protein 1 antikoerper, discs, large homolog 1 (Drosophila) antikoerper, DLG1 antikoerper, Dlg1 antikoerper

Hintergrund:

Synonyms: Discs large homolog 1, Disks large homolog 1, DLG 1, DLG1, DLG1_HUMAN, DLGH 1, DLGH1, HDLG, Presynaptic protein SAP97, SAP 97, SAP-97, SAP97, Synapse associated protein 97, Synapse-associated protein 97

Background: The discs large (dlg) tumor suppressor gene was first identified in Drosophila through genetic analysis of germline mutations. Several mammalian homologs were subsequently identified and categorized into a protein family designated MAGUK (membrane-associated guanylate kinase homolog). The mammalian homolog of dlg, SAP 97, is also known as hdlg-1 (human) and NE-dlg (neuronal and endocrine). The rat synaptic protein SAP 90 (also designated PSD-95) also shares homology with these proteins. MAGUKs are localized at the membrane-cytoskeleton interface and contain several distinct domains which suggest a role for these proteins in intracellular signal transduction. Interaction of hdlg-1 and NE-dlg with the tumor suppresor protein APC suggest that MAGUK proteins may also play a role in regulation of growth.

Gen-ID: 1739

Pathways: Regulation of Actin Filament Polymerization, Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response