CXCR7 Antikörper (AA 151-250)

Produktnummer ABIN1387536

Produktdetails anti-CXCR7 Antikörper

Target: CXCR7 (Chemokine (C-X-C Motif) Receptor 7 (CXCR7))

Bindungsspezifität: AA 151-250

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CXCR7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Kreuzreaktivität: Human, Ratte

Homologie: Mouse,Dog,Cow,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CXCR7/RDC1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-CXCR7 Antikörper (ABIN1387536)

Cao, Song, Ge, Song, Chen, Wu: "MicroRNA-100 suppresses human gastric cancer cell proliferation by targeting CXCR7." in: Oncology letters, Vol. 15, Issue 1, pp. 453-458, (2018) (PubMed).

Details zu CXCR7

Target: CXCR7 (Chemokine (C-X-C Motif) Receptor 7 (CXCR7))

Andere Bezeichnung: CXCR7/RDC1 (CXCR7 Produkte)

Synonyme: CMKOR1 antikoerper, CXC-R7 antikoerper, CXCR-7 antikoerper, CXCR7 antikoerper, GPR159 antikoerper, RDC-1 antikoerper, RDC1 antikoerper, AW541270 antikoerper, Cmkor1 antikoerper, Cxcr7 antikoerper, Rdc1 antikoerper, ackr3 antikoerper, cxcr7 antikoerper, rdc1 antikoerper, xcxcr7 antikoerper, atypical chemokine receptor 3 antikoerper, ORF 74; similar to Kaposi's sarcoma-associated herpesvirus ORF 74 antikoerper, atypical chemokine receptor 3 L homeolog antikoerper, ACKR3 antikoerper, MmrVgp88 antikoerper, Ackr3 antikoerper, ackr3.L antikoerper

Hintergrund:

Synonyms: RDC1, CXCR7, RDC-1, CMKOR1, CXC-R7, CXCR-7, GPR159, Atypical chemokine receptor 3, C-X-C chemokine receptor type 7, Chemokine orphan receptor 1, G-protein coupled receptor 159, G-protein coupled receptor RDC1 homolog, ACKR3

Background: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.

Gen-ID: 57007

UniProt: P25106

Pathways: Myometrial Relaxation and Contraction, Negative Regulation of intrinsic apoptotic Signaling