PEN2 Antikörper (AA 6-80)

Produktnummer ABIN1387540

Produktdetails anti-PEN2 Antikörper

Target: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Bindungsspezifität: AA 6-80

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PEN2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität: Belongs to the PEN-2 family

Kreuzreaktivität: Maus, Ratte

Homologie: Human,Dog,Cow,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PEN2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-PEN2 Antikörper (ABIN1387540)

Chu, Peng, Long, Wang, Luo, Sharma, He: "Distribution and expression of Pen-2 in the central nervous system of APP/PS1 double transgenic mice." in: Acta biochimica et biophysica Sinica, Vol. 47, Issue 4, pp. 258-66, (2015) (PubMed).

Details zu PEN2

Target: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Andere Bezeichnung: PEN2 (PSENEN Produkte)

Synonyme: MSTP064 antikoerper, PEN-2 antikoerper, PEN2 antikoerper, Psenen antikoerper, ACYPI006208 antikoerper, 1700023M09Rik antikoerper, Pen-2 antikoerper, RGD1312037 antikoerper, CG33198 antikoerper, Dmel\\CG33198 antikoerper, anon-AE003800.1 antikoerper, dPen-2 antikoerper, psenen antikoerper, pen-2 antikoerper, pen2 antikoerper, zgc:109727 antikoerper, presenilin enhancer gamma-secretase subunit antikoerper, presenilin enhancer 2 antikoerper, presenilin enhancer gamma secretase subunit antikoerper, Gamma-secretase subunit pen-2 antikoerper, presenilin enhancer antikoerper, presenilin enhancer gamma secretase subunit S homeolog antikoerper, PSENEN antikoerper, PEN2 antikoerper, Psenen antikoerper, pen-2 antikoerper, psenen.S antikoerper, psenen antikoerper

Hintergrund:

Synonyms: PEN2, PEN-2, MDS033, MSTP064, Gamma-secretase subunit PEN-2, Presenilin enhancer protein 2, PSENEN

Background: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.

Gen-ID: 55851

UniProt: Q9NZ42

Pathways: Notch Signalweg, Neurotrophin Signalübertragung