MYLIP Antikörper (AA 65-103)

Produktnummer ABIN1387567

Produktdetails anti-MYLIP Antikörper

Target: MYLIP (Myosin Regulatory Light Chain Interacting Protein (MYLIP))

Bindungsspezifität: AA 65-103

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MYLIP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MYLIP

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu MYLIP

Target: MYLIP (Myosin Regulatory Light Chain Interacting Protein (MYLIP))

Andere Bezeichnung: MYLIP (MYLIP Produkte)

Synonyme: IDOL antikoerper, MIR antikoerper, 9430057C20Rik antikoerper, Mir antikoerper, mylip antikoerper, wu:fj36b03 antikoerper, zgc:55987 antikoerper, MYLIP antikoerper, mir antikoerper, zgc:153767 antikoerper, myosin regulatory light chain interacting protein antikoerper, myosin regulatory light chain interacting protein a antikoerper, myosin regulatory light chain interacting protein L homeolog antikoerper, myosin regulatory light chain interacting protein b antikoerper, MYLIP antikoerper, Mylip antikoerper, mylipa antikoerper, mylip.L antikoerper, mylip antikoerper, mylipb antikoerper

Hintergrund:

Synonyms: MIR, IDOL, E3 ubiquitin-protein ligase MYLIP, Inducible degrader of the LDL-receptor, Myosin regulatory light chain interacting protein, MYLIP, BZF1, BM-023, PP5242

Background: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.

Gen-ID: 29116

UniProt: Q8WY64