DEPTOR Antikörper (AA 56-170)

Produktnummer ABIN1387597

Produktdetails anti-DEPTOR Antikörper

Target: DEPTOR (DEP Domain Containing mTOR-Interacting Protein (DEPTOR))

Bindungsspezifität: AA 56-170

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DEPTOR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DEPTOR/DEPDC6

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-DEPTOR Antikörper (ABIN1387597)

Liu, Cai, Zhang, Liu, Luo, Xing, Du: "Deacetylation of NAT10 by Sirt1 promotes the transition from rRNA biogenesis to autophagy upon energy stress." in: Nucleic acids research, Vol. 46, Issue 18, pp. 9601-9616, (2019) (PubMed).

Liu, Zhang, Liu, Li, Zhang, Li, Liu, Huang, Shen, Gu, Gao, Wu, Wu: "High DEPTOR expression correlates with poor prognosis in patients with esophageal squamous cell carcinoma." in: OncoTargets and therapy, Vol. 8, pp. 3449-55, (2015) (PubMed).

Details zu DEPTOR

Target: DEPTOR (DEP Domain Containing mTOR-Interacting Protein (DEPTOR))

Andere Bezeichnung: Deptor (DEPTOR Produkte)

Synonyme: DEP.6 antikoerper, DEPDC6 antikoerper, 4731402B04Rik antikoerper, 9130412E02Rik antikoerper, D15Ertd336e antikoerper, D15Ertd597e antikoerper, Depdc6 antikoerper, Depdc6-001 antikoerper, Depdc6-002 antikoerper, R75183 antikoerper, mKIAA4200 antikoerper, RGD1561030 antikoerper, RAPGEF4 antikoerper, DEP domain containing MTOR interacting protein antikoerper, DEP domain containing MTOR-interacting protein antikoerper, DEPTOR antikoerper, Deptor antikoerper

Hintergrund:

Synonyms: DEP.6, DEPDC6, DEP domain-containing mTOR-interacting protein, DEP domain-containing protein 6, DEPTOR

Background: DEPTOR (DEP domain containing MTOR-interacting protein), also known as DEP.6 or DEPDC6 (DEP domain-containing protein 6), is a 409 amino acid protein that negatively regulates mTORC1 and mTORC2 pathways. DEPTOR interacts with FRAP via its PDZ domain, and undergoes post-translational phosphorylation. Containing two DEP domains and one PDZ (DHR) domain, DEPTOR is encoded by a gene that maps to human chromosome 8q24.12. Chromosome 8 consists of nearly 146 million base pairs, encodes over 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that map to chromosome 8.

Gen-ID: 64798

UniProt: Q8TB45

Pathways: PI3K-Akt Signalweg, RTK Signalweg, Regulation of Cell Size, BCR Signaling, Warburg Effekt