FAM126A Antikörper (AA 1-100)

Produktnummer ABIN1387791

Produktdetails anti-FAM126A Antikörper

Target: FAM126A (Family with Sequence Similarity 126, Member A (FAM126A))

Bindungsspezifität: AA 1-100

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FAM126A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc))

Kreuzreaktivität: Human, Maus

Homologie: Rat,Dog,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Hyccin

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu FAM126A

Target: FAM126A (Family with Sequence Similarity 126, Member A (FAM126A))

Andere Bezeichnung: FAM126A/Hyccin (FAM126A Produkte)

Synonyme: DRCTNNB1A antikoerper, HCC antikoerper, HLD5 antikoerper, HYCC1 antikoerper, AB030242 antikoerper, Drctnnb1a antikoerper, RGD1562906 antikoerper, zgc:77228 antikoerper, fam126a antikoerper, family with sequence similarity 126 member A antikoerper, family with sequence similarity 126, member A antikoerper, family with sequence similarity 126 member A S homeolog antikoerper, FAM126A antikoerper, Fam126a antikoerper, fam126a antikoerper, fam126a.S antikoerper

Hintergrund:

Synonyms: Down regulated by Ctnnb1 a, Down regulated by CTNNB1 protein A, Down-regulated by CTNNB1 protein A, DRCTNNB1A, FAM126A, Family with sequence similarity 126 member A, HCC, HLD5, HYCC1, HYCCI_HUMAN antibody Hyccin, Protein FAM126A.

Background: Hyccin is a 521 amino acid cytoplasmic protein that is widely expressed with highest levels found in heart, brain, placenta, spleen and testis. Belonging to the FAM126 family, hyccin may play a role in the -catenin/Lef signaling pathway. Hyccin is likely involved in the process of myelination of the central and peripheral nervous system. Defects in the gene encoding hyccin are the cause of leukodystrophy hypomyelinating type 5 (HLD5), which is characterized by congenital cataract, progressive neurologic impairment and diffuse myelin deficiency. Individuals affected by HLD5 experience progressive pyramidal and cerebellar dysfunction along with muscle weakness in the lower limbs. Hyccin exists as two alternatively spliced isoforms and is encoded by a gene located on human chromosome 7.