DOCK3 Antikörper (AA 1001-1100)

Produktnummer ABIN1387818

Produktdetails anti-DOCK3 Antikörper

Target: DOCK3 (Dedicator of Cytokinesis 3 (DOCK3))

Bindungsspezifität: AA 1001-1100

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DOCK3 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc))

Homologie: Human,Mouse,Rat,Dog,Pig,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DOCK3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu DOCK3

Target: DOCK3 (Dedicator of Cytokinesis 3 (DOCK3))

Andere Bezeichnung: DOCK3 (DOCK3 Produkte)

Synonyme: MOCA antikoerper, PBP antikoerper, mKIAA0299 antikoerper, dedicator of cytokinesis 3 antikoerper, similar to dedicator of cytokinesis 3 antikoerper, dedicator of cytokinesis protein 3 antikoerper, dedicator of cyto-kinesis 3 antikoerper, DOCK3 antikoerper, LOC561387 antikoerper, dock3 antikoerper, LOC100474164 antikoerper, Dock3 antikoerper

Hintergrund:

Synonyms: Dedicator of cytokinesis protein 3, DOCK 3, MOCA, Modier of cell adhesion, Presenilin binding protein, DOCK3_HUMAN.

Background: MOCA (modifier of cell adhesion), also known as Presenilin-binding protein (PBP) or dedicator of cytokinesis protein 3 (DOCK3), is a 2030 amino acid cytoplasmic protein belonging to the DOCK family. MOCA interacts with Presenilin proteins and has the ability to stimulate Tau phosphorylation suggesting that MOCA may be involved in Alzheimer disease. MOCA is also thought to be a guanine nucleotide exchange factor (GEF) which activates small GTPases by exchanging bound GDP for free GTP. Analysis of ectopic expression suggests that MOCA may affect the function of small GTPases involved in the regulation of Actin cytoskeleton or cell adhesion receptors. MOCA is localized to the neuropil, and sometimes in pyramidal cells, in normal brains, while in Alzheimer disease brains, MOCA is present in neurofibrillary tangles.