Netrin 4 Antikörper (AA 520-628) (Biotin)

Produktnummer ABIN1388437

Produktdetails anti-Netrin 4 Antikörper (Biotin)

Target: Netrin 4 (NTN4)

Bindungsspezifität: AA 520-628

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Netrin 4 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Netrin 4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu Netrin 4

Target: Netrin 4 (NTN4)

Andere Bezeichnung: Netrin 4 (NTN4 Produkte)

Synonyme: Netrin-4 antikoerper, PRO3091 antikoerper, RGD1565947 antikoerper, netrin 4 antikoerper, netrin-4 antikoerper, NTN4 antikoerper, ntn4 antikoerper, Ntn4 antikoerper, LOC100541214 antikoerper

Hintergrund:

Synonyms: Beta netrin, Beta-netrin, Hepar derived netrin like protein, Hepar-derived netrin-like protein, NET4_HUMAN, Netrin-4, Netrin4, NTN 4, NTN4.

Background: Netrin proteins are a family of laminin-related secreted proteins that provide guidance signals for axonal growth and cell migration during development. Netrin signaling is dependent on the concentration of calcium outside the cell and the level of PKA activity. In axonal cells, a reduction in PKA activity converts the responsiveness of the axons to the netrin proteins, as the cells are repelled, rather than attracted, by the netrin gradient. Netrin-4 is related to the Laminin chains, and is therefore also designated -netrin. It is present in the basement membranes of the vasculature, lateral olfactory tract, kidney and ovary. In humans, the gene encoding for the netrin-4 protein is localized to chromosome 12q22-q23. High levels of netrin-4 mRNA have also been detected in many cells and tissues, including cerebral cortex, hippocampus, amygdaloid nuclei and Purkinje cells. Netrin-4 is important in neural, kidney and vascular development.

Gen-ID: 59277