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AAV VP1 Antikörper (AbBy Fluor® 647)

AAV VP1 Reaktivität: Adeno-Associated Virus (AAV) IF (cc), IF (p) Wirt: Kaninchen Polyclonal AbBy Fluor® 647
Produktnummer ABIN1388676
  • Target Alle AAV VP1 Produkte
    AAV VP1 (Adeno-Associated Virus, VP1 (AAV VP1))
    Reaktivität
    Adeno-Associated Virus (AAV)
    Wirt
    • 13
    Kaninchen
    Klonalität
    • 13
    Polyklonal
    Konjugat
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser AAV VP1 Antikörper ist konjugiert mit AbBy Fluor® 647
    Applikation
    • 11
    • 11
    • 3
    • 3
    • 3
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Spezifität
    This antibody will recognize many AAV strains, including AAV5, AAV4, AAV3B, AAV9, and AAV13
    Kreuzreaktivität
    Virus
    Kreuzreaktivität (Details)
    AAV5
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from Adeno-Associated Virus 5 capsid protein VP1
    Isotyp
    IgG
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    AAV VP1 (Adeno-Associated Virus, VP1 (AAV VP1))
    Andere Bezeichnung
    Adeno-Associated Virus Capsid Protein VP1 (AAV VP1 Produkte)
    Substanzklasse
    Viral Protein
    Hintergrund

    Synonyms: capsid protein Adeno-associated 5 virus, capsid protein [Adeno-associated virus - 5], capsid protein AAV5, Parvovirus coat protein VP1, capsid protein.

    Background: Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of three size variants of the capsid protein VP1, VP2 and VP3 which differ in their N-terminus. The capsid encapsulates the genomic ssDNA. Binds to host cell heparan sulfate and uses host ITGA5-ITGB1 as coreceptor on the cell surface to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptor also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and putative nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus

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