C9 Antikörper (AA 161-260) (AbBy Fluor® 350)

Produktnummer ABIN1389807

Produktdetails anti-C9 Antikörper (AbBy Fluor® 350)

Target: C9 (Complement Component C9 (C9))

Bindungsspezifität: AA 161-260

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser C9 Antikörper ist konjugiert mit AbBy Fluor® 350

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Kreuzreaktivität: Human

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Complement component C9a

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM 1:20-100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu C9

Target: C9 (Complement Component C9 (C9))

Andere Bezeichnung: C9a/C9 (C9 Produkte)

Synonyme: LOC100037951 antikoerper, LOC100136130 antikoerper, c9 antikoerper, wu:fb60b05 antikoerper, wu:fd50e04 antikoerper, zgc:112272 antikoerper, complement C9 antikoerper, complement component 9 antikoerper, complement component 9 L homeolog antikoerper, C9 antikoerper, c9 antikoerper, c9.L antikoerper

Hintergrund:

Synonyms: C9a, C9 deficiency, C9 deficiency with dermatomyositis, CO9_HUMAN, Complement component 9, Complement component 9 deficiency, Complement component C9a, Complement component C9a, C9.

Background: C9 is a plasma protein synthesized in the liver and monocytes consisting of a single polypeptide chain. C9 is a part of the membrane attack complex (MAC), an important component of the immune system. The MAC forms upon complement system activation by invading pathogenic bacteria and consists of the four major complement proteins: C5b, C6, C7 and C8. These complement proteins bind to the outer surface of the plasma membrane of the invading cell. C9 binds to the membrane associated C5b-8 protein, which leads to the circular polymerization of 12-18 C9 Molecules. These polymerized C9 Molecules form a ring structure in the membrane. Molecules can then diffuse freely through this transmembrane channel, causing cell lysis and destruction of the invading bacterial cell.

Pathways: Komplementsystem