Chromosome 11open Reading Frame 9 (C11orf9) (AA 401-500) Antikörper (Biotin)

Produktnummer ABIN1389817

Produktdetails

Target: Chromosome 11open Reading Frame 9 (C11orf9)

Bindungsspezifität: AA 401-500

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MYRF

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Antigendetails

Target: Chromosome 11open Reading Frame 9 (C11orf9)

Andere Bezeichnung: MYRF/C11orf9 (C11orf9 Produkte)

Synonyme: C11orf9 antikoerper, c11orf9 antikoerper, mrf antikoerper, ndt80 antikoerper, MRF antikoerper, Ndt80 antikoerper, pqn-47 antikoerper, 6030439E18 antikoerper, Gm1804 antikoerper, Gm98 antikoerper, Mrf antikoerper, chromosome 5 open reading frame, human C11orf9 antikoerper, myelin regulatory factor L homeolog antikoerper, myelin regulatory factor antikoerper, C5H11ORF9 antikoerper, myrf.L antikoerper, MYRF antikoerper, Myrf antikoerper

Hintergrund:

Synonyms: MRF, Ndt80, pqn-47, C11orf9, Myelin regulatory factor, Myelin gene regulatory factor, MYRF, KIAA0954

Background: Myelin regulatory factor: Consitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes (PubMed:23966832). Myelin regulatory factor, C-terminal: Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage. Myelin regulatory factor, N-terminal: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifically recognizes and binds DNA sequence 5'-CTGGYAC-3' in the regulatory regions of myelin-specific genes and directly activates their expression. Not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype (PubMed:23966832).

Gen-ID: 745

UniProt: Q9Y2G1