MTMR14 Antikörper (AA 161-260) (AbBy Fluor® 488)

Produktnummer ABIN1389964

Produktdetails anti-MTMR14 Antikörper (AbBy Fluor® 488)

Target: MTMR14 (Myotubularin Related Protein 14 (MTMR14))

Bindungsspezifität: AA 161-260

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MTMR14 Antikörper ist konjugiert mit AbBy Fluor® 488

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Maus

Homologie: Human,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MTMR14

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu MTMR14

Target: MTMR14 (Myotubularin Related Protein 14 (MTMR14))

Andere Bezeichnung: MTMR14 (MTMR14 Produkte)

Synonyme: fc14d11 antikoerper, wu:fc14d11 antikoerper, MGC131146 antikoerper, C3orf29 antikoerper, 1110061O04Rik antikoerper, AW553738 antikoerper, C76151 antikoerper, RGD1304842 antikoerper, jumpy antikoerper, myotubularin related protein 14 antikoerper, myotubularin-related protein 14 antikoerper, myotubularin related protein 14 S homeolog antikoerper, mtmr14 antikoerper, LOC703936 antikoerper, mtmr14.S antikoerper, MTMR14 antikoerper, Mtmr14 antikoerper

Hintergrund:

Synonyms: C3orf29, Egg derived tyrosine phosphatase homolog, FLJ11546, FLJ22405, FLJ46453, FLJ90311, HCV NS5A transactivated protein 4 splice variant A binding protein 1, HCV NS5A-transactivated protein 4 splice variant A-binding protein 1, hJumpy, jumpy, MTMR 14, MTMR14, MTMR-14, MTMRE_HUMAN, Myotubularin related protein 14, Myotubularin-related protein 14, NS5ATP4ABP1.

Background: Myotubularin-related protein 14 (MTMR14), also known as Jumpy, is a myotubularin-related phosphoinositol-3-phosphate (PI3P) phosphatase (1). Mutations in the MTMR14 gene have been associated with centronuclear myopathy (1). MTMR14 deficiency in mice leads to altered calcium homeostasis and muscle disorders (2). MTMR14 has also been shown to play a role in autophagy, a process that is highly regulated by phosphatidylinositides through the type III PI3K, Vps34 (3). MTMR14 was localized to autophagic isolation membranes and early autophagosomes (3). In these studies, MTMR14 inhibited autophagy and mutations of MTMR14 associated with centronuclear myopathy were also defective in autophagy inhibition. In zebrafish, MTMR14 knockdown was shown to increase the number of autophagosomes, suggesting that its activity is associated with an inhibition of autophagy (4).

Pathways: Inositol Metabolic Process