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MCPH1 Antikörper (AA 11-110) (AbBy Fluor® 488)

MCPH1 Reaktivität: Maus WB, IF (cc), IF (p) Wirt: Kaninchen Polyclonal AbBy Fluor® 488
Produktnummer ABIN1390024
  • Target Alle MCPH1 Antikörper anzeigen
    MCPH1 (Microcephalin 1 (MCPH1))
    Bindungsspezifität
    • 14
    • 11
    • 9
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 11-110
    Reaktivität
    • 42
    • 22
    • 4
    • 1
    Maus
    Wirt
    • 49
    • 6
    • 1
    Kaninchen
    Klonalität
    • 51
    • 5
    Polyklonal
    Konjugat
    • 26
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MCPH1 Antikörper ist konjugiert mit AbBy Fluor® 488
    Applikation
    • 48
    • 25
    • 12
    • 12
    • 10
    • 4
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Maus
    Homologie
    Human,Dog
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Microcephalin 1/BRIT1
    Isotyp
    IgG
    Top Product
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  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    MCPH1 (Microcephalin 1 (MCPH1))
    Andere Bezeichnung
    Microcephalin 1/BRIT1 (MCPH1 Produkte)
    Synonyme
    RGD1560642 antikoerper, MGC83773 antikoerper, MCPH1 antikoerper, mct antikoerper, brit1 antikoerper, MGC148665 antikoerper, BRIT1 antikoerper, MCT antikoerper, 5430437K10Rik antikoerper, D030046N04Rik antikoerper, microcephalin 1 antikoerper, microcephalin 1 S homeolog antikoerper, microcephaly, primary autosomal recessive 1 antikoerper, Mcph1 antikoerper, mcph1.S antikoerper, MCPH1 antikoerper, mcph1 antikoerper
    Hintergrund

    Synonyms: BRCT repeat inhibitor of TERT expression 1, BRIT 1, FLJ12847, Hypothetical protein FLJ12847, MCPH 1, MCPH1, MCPH1_HUMAN, MCT antibody Microcephalin 1, Microcephalin-1, Microcephaly primary autosomal recessive 1.

    Background: Microcephalin modulates brain size and has been proliferating under strong positive selection for several thousand years, although the nature of the positive selection is poorly understood. Human Microcephalin contains three BRCA1 C-terminal (BRCT) domains and shares 57 % identity with its mouse ortholog, the most conserved regions being BRCT domains where there is 80 % identity. Predominant expression of human Microcephalin is observed in fetal brain, liver and kidney tissues and is expressed during neurogenesis in mice. Microcephalin displays significantly higher rates of protein evolution in primates than in rodents, this trend is most noticeable for the subset of genes associated with nervous system development. Microcephalin has a very young, single nucleotide, polymorphism haplotype associated with modern humans, this gene is presumably still evolving in Homo sapiens. It functions in DNA damage response and regulation of cell cycle checkpoints.

    Pathways
    Stem Cell Maintenance
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