CCT2 Antikörper (AA 131-230) (Biotin)

Produktnummer ABIN1390255

Produktdetails anti-CCT2 Antikörper (Biotin)

Target: CCT2 (Chaperonin Containing TCP1, Subunit 2 (Beta) (CCT2))

Bindungsspezifität: AA 131-230

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CCT2 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus

Homologie: Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit,Zebrafish

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CCT2/TCP1 beta

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu CCT2

Target: CCT2 (Chaperonin Containing TCP1, Subunit 2 (Beta) (CCT2))

Andere Bezeichnung: CCT2/TCP1 beta (CCT2 Produkte)

Synonyme: fa26a01 antikoerper, fc58a11 antikoerper, CHUNP6883 antikoerper, wu:fa26a01 antikoerper, wu:fc58a11 antikoerper, cct2 antikoerper, MGC89448 antikoerper, CCT2 antikoerper, 99D8.1 antikoerper, CCT-beta antikoerper, CCTB antikoerper, PRO1633 antikoerper, TCP-1-beta antikoerper, Cctb antikoerper, chaperonin containing TCP1 subunit 2 antikoerper, chaperonin containing TCP1, subunit 2 (beta) antikoerper, chaperonin containing Tcp1, subunit 2 (beta) antikoerper, T-complex protein 1 subunit beta antikoerper, CCT2 antikoerper, cct2 antikoerper, Cct2 antikoerper, cct-2 antikoerper

Hintergrund:

Synonyms: CCT 2, CCT beta, CCT-beta, CCT-2, CCTB, Chaperonin containing t complex polypeptide 1 beta subunit, Chaperonin containing t complex polypeptide 1 subunit 2, Chaperonin containing TCP1 subunit 2, Chaperonin containing TCP1 subunit 2 beta, CTP:phosphocholine cytidylyltransferase 2, MGC142074, MGC142076, MGC94480, PRO1633, T complex protein 1 beta subunit, T complex protein 1 subunit beta, T-complex protein 1 subunit beta, TCP 1 beta, TCP-1-beta, TCPB_HUMAN, 99D8.1.

Background: CCT2 is one of eight largely unrelated subunit proteins found in a protein chaperone complex known as the chaperonin-containing TCP-1 (CCT) or TRiC complex. The CCT complex is an abundanct cytoslic component that is credited with helping newly synthesized polypeptides adopt the correct conformation (1). Proteins that fold and assemble with the help of CCT include the cytoskeletal proteins actin and tubulin as well as up to 15 % of newly synthesized eukaryotic proteins (2). CCT2 is the _-subunit of the chaperone complex and is one of several CCT proteins that exhibit increased expression in response to stress. This implies that the CCT complex helps cells recover from protein damage by assisting in protein folding and assembly (3). CCT subunit levels also change throughout the cell cycle, with lower proteins levels (and reduced chaperone activity) found during induced cell cycle arrest during at M phase (4). Each CCT subunit is thought to perform a specific function during protein folding and assembly (5), CCT2 exhibits both actin and tubulin binding activities (6,3) but the exact molecular function on this subunit remains uncertain.